PMID- 30392901
OWN - NLM
STAT- MEDLINE
DCOM- 20190517
LR  - 20190517
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 52
DP  - 2019 Jan
TI  - What magnetic resonance imaging reveals - A systematic review of the relationship 
      between type II diabetes and associated brain distortions of structure and 
      cognitive functioning.
PG  - 79-112
LID - S0091-3022(18)30057-8 [pii]
LID - 10.1016/j.yfrne.2018.10.001 [doi]
AB  - Due to its increasing prevalence, Type 2 diabetes mellitus (T2DM) represents a 
      major health challenge for modern society. Despite it being of fundamental 
      interest, only a few MRI studies have conducted statistical analyses to draw 
      scientifically valid conclusions about the complex interplay of T2DM and its 
      associated clinical, structural, functional, metabolite, as well as cognitive 
      distortions. Therefore, a systematic review of 68 manuscripts, following the 
      PRISMA guidelines, was conducted. Notably, although the associations between 
      imaging, clinical, and cognitive variables are not fully homogeneous, findings 
      show a clear trend towards a link between altered brain structure and a decline 
      in cognitive processing ability. The results of the review highlight the 
      heterogeneity of the methods used across manuscripts in terms of assessed 
      clinical variables, imaging, and data analysis methods. This is particularly 
      significant as, if the subjects' criteria are not carefully considered, results 
      are easily prone to confounding factors.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Rosenberg, Jessica
AU  - Rosenberg J
AD  - Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, 
      Forschungszentrum Julich GmbH, 52425 Julich, Germany; JARA - Translational Brain 
      Medicine & INM-11, RWTH Aachen University, 52074 Aachen, Germany; Department of 
      Neurology, University Clinic Aachen, 52074 Aachen, Germany. Electronic address: 
      j.rosenberg@fz-juelich.de.
FAU - Lechea, Nazim
AU  - Lechea N
AD  - Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, 
      Forschungszentrum Julich GmbH, 52425 Julich, Germany.
FAU - Pentang, Gael N
AU  - Pentang GN
AD  - Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, 
      Forschungszentrum Julich GmbH, 52425 Julich, Germany.
FAU - Shah, Nadim J
AU  - Shah NJ
AD  - Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, 
      Forschungszentrum Julich GmbH, 52425 Julich, Germany; JARA - Translational Brain 
      Medicine & INM-11, RWTH Aachen University, 52074 Aachen, Germany; Department of 
      Neurology, University Clinic Aachen, 52074 Aachen, Germany; Department of 
      Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, 
      School of Psychological Sciences, Monash University, Melbourne, Victoria, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20181028
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
SB  - IM
MH  - *Brain Diseases/diagnostic imaging/etiology/pathology/physiopathology
MH  - *Cognitive Dysfunction/diagnostic imaging/etiology/pathology/physiopathology
MH  - *Diabetes Mellitus, Type 2/complications/diagnostic 
      imaging/pathology/physiopathology
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - *Neuroimaging
OTO - NOTNLM
OT  - Brain
OT  - Cognition
OT  - DTI
OT  - Functional MRI
OT  - Neurodegeneration
OT  - Type 2 diabetes mellitus
EDAT- 2018/11/06 06:00
MHDA- 2019/05/18 06:00
CRDT- 2018/11/06 06:00
PHST- 2018/05/24 00:00 [received]
PHST- 2018/10/11 00:00 [revised]
PHST- 2018/10/22 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/05/18 06:00 [medline]
PHST- 2018/11/06 06:00 [entrez]
AID - S0091-3022(18)30057-8 [pii]
AID - 10.1016/j.yfrne.2018.10.001 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2019 Jan;52:79-112. doi: 10.1016/j.yfrne.2018.10.001. Epub 
      2018 Oct 28.