PMID- 30393042
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20190507
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 127
DP  - 2018 Dec
TI  - Dermatoglyphics in children prenatally exposed to alcohol: Fluctuating asymmetry 
      (FA) as a biomarker of alcohol exposure.
PG  - 90-95
LID - S0378-3782(18)30352-9 [pii]
LID - 10.1016/j.earlhumdev.2018.10.007 [doi]
AB  - BACKGROUND: Dermatoglyphics alterations have been demonstrated to be an effective 
      complement in the diagnosis of developmental disorders and a marker of prenatal 
      stress. Several genetic and environmental factors can modify their morphology. 
      Once defined, dermatoglyphics remain constant throughout life, being considered 
      fossilized markers of the intrauterine development. Variations in bilateral 
      morphological traits within an individual reflect developmental disturbances and 
      can be measured by fluctuating asymmetry. The aim of this study was to evaluate 
      if dermatoglyphic variations can be used as a surrogate marker prenatal alcohol 
      exposure (PAE) during foetal development. Dermatoglyphics from 58 individuals who 
      were either exposed or non-exposed to alcohol during pregnancy (according to the 
      levels of Fatty Acid Ethyl Ethers (FAEE) found in meconium at birth) were 
      analyzed. METHODS: Total a-b ridge count (TABRC) and levels of fluctuating 
      asymmetry from the a-b ridge count (FA(ABRC)) were obtained. RESULTS: A 
      significant correlation between FA and FAEE levels was found in prenatally 
      alcohol exposed individuals (r = 0.64, p = 0.0032). Remarkably, samples with 
      highest values of FAEEs showed greater FA(ABRC) (6.33 +/- 4.18) levels than the 
      values of non-exposed to alcohol (2.87 +/- 1.74) as well as the exposed at low 
      concentrations (2.6 +/- 1.43) (U = 61, p = 0.05 and U = 14.5, p = 0.05, 
      respectively). CONCLUSION: Heavy prenatal ethanol exposure (demonstrated by high 
      levels of FAEEs) alters the neuroectoderm developmental program during pregnancy: 
      PAE correlates with FA(ABRC), which behaves as a dermatoglyphic variable 
      sensitive to FASD and deserves to be studied as a surrogate marker of 
      neurodevelopmental damage during foetal development.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Planas, Sabina
AU  - Planas S
AD  - Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva, 
      Ecologia i Ciencies Ambientals, Facultat de Biologia, Universitat de Barcelona 
      (UB), Barcelona, Spain.
FAU - Andreu-Fernandez, Vicente
AU  - Andreu-Fernandez V
AD  - Grup de Recerca Infancia i Entorn (GRIE), Servicio de Neonatologia, Hospital 
      Clinic-Maternitat, ICGON, IDIBAPS, BCNatal, Barcelona, Spain; Red de Salud 
      Materno-Infantil y del Desarrollo (SAMID), Programa RETICS, Instituto de Salud 
      Carlos III, Madrid, Spain.
FAU - Martin, Maria
AU  - Martin M
AD  - Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva, 
      Ecologia i Ciencies Ambientals, Facultat de Biologia, Universitat de Barcelona 
      (UB), Barcelona, Spain.
FAU - de Castro-Catala, Marta
AU  - de Castro-Catala M
AD  - Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva, 
      Ecologia i Ciencies Ambientals, Facultat de Biologia, Universitat de Barcelona 
      (UB), Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona 
      (IBUB), Barcelona, Spain.
FAU - Bastons-Compta, Adriana
AU  - Bastons-Compta A
AD  - Grup de Recerca Infancia i Entorn (GRIE), Servicio de Neonatologia, Hospital 
      Clinic-Maternitat, ICGON, IDIBAPS, BCNatal, Barcelona, Spain; Red de Salud 
      Materno-Infantil y del Desarrollo (SAMID), Programa RETICS, Instituto de Salud 
      Carlos III, Madrid, Spain.
FAU - Garcia-Algar, Oscar
AU  - Garcia-Algar O
AD  - Grup de Recerca Infancia i Entorn (GRIE), Servicio de Neonatologia, Hospital 
      Clinic-Maternitat, ICGON, IDIBAPS, BCNatal, Barcelona, Spain; Red de Salud 
      Materno-Infantil y del Desarrollo (SAMID), Programa RETICS, Instituto de Salud 
      Carlos III, Madrid, Spain.
FAU - Rosa, Araceli
AU  - Rosa A
AD  - Seccio de Zoologia i Antropologia Biologica, Departament de Biologia Evolutiva, 
      Ecologia i Ciencies Ambientals, Facultat de Biologia, Universitat de Barcelona 
      (UB), Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona 
      (IBUB), Barcelona, Spain; Centre for Biomedical Research Network on Mental Health 
      (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: 
      araceli.rosa@ub.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181028
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
RN  - 0 (Biomarkers)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Biomarkers
MH  - *Dermatoglyphics
MH  - Ethanol/*toxicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*diagnosis
OTO - NOTNLM
OT  - Dermatoglyphics
OT  - Developmental instability
OT  - FAEE
OT  - Fluctuating asymmetry
OT  - Meconium
OT  - Prenatal alcohol exposure (PAE)
EDAT- 2018/11/06 06:00
MHDA- 2019/05/08 06:00
CRDT- 2018/11/06 06:00
PHST- 2018/05/25 00:00 [received]
PHST- 2018/10/17 00:00 [revised]
PHST- 2018/10/20 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2018/11/06 06:00 [entrez]
AID - S0378-3782(18)30352-9 [pii]
AID - 10.1016/j.earlhumdev.2018.10.007 [doi]
PST - ppublish
SO  - Early Hum Dev. 2018 Dec;127:90-95. doi: 10.1016/j.earlhumdev.2018.10.007. Epub 
      2018 Oct 28.