PMID- 30394721
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20190306
IS  - 2448-5667 (Electronic)
IS  - 0443-5117 (Linking)
VI  - 56
IP  - 3
DP  - 2018 Oct 25
TI  - [Multicentric insulinoma associated with multiple endocrine neoplasia type 1: One 
      case report].
PG  - 316-319
LID - http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/article/view/1526/3011 
      [pii]
AB  - BACKGROUND: Pancreatic neuroendocrine tumors may be associated with multiple 
      endocrine neoplasia type 1 (MEN1) in 15-25% of cases, and up to 10% develop 
      insulinomas, which are the most frequent cause of persistent hyperinsulinemic 
      hypoglycemia in adults. The objective is to show a clinical case that presents 
      this association. CLINICAL CASE: 36-year-old patient with seizures associated 
      with fasting hypoglycemia of 36 mg/dL. The patient presented high levels of 
      insulin, peptide C, proinsulin, hypercalcemia, hypophosphatemia and parathyhroid 
      hormone. Ultrasound sonography test showed hypoechoic lesion in the pancreatic 
      tail of 2.3 cm. Tomography showed a 10 mm hypodense lesion at pancreatic head. 
      Scintigram showed hypercaptating parathyroid tissue. Magnetic resonance did not 
      show evidence of pituitary adenoma. We carried out a tumor enucleation of the 
      pancreatic head and distal partial pancreatectomy with histopathological 
      diagnosis of well-differentiated low-grade multifocal neuroendocrine tumor (five 
      tumors); two tumors were immunoreactive to insulin. After surgery, glucose level 
      was normalized (105 mg/dL). Patient underwent parathyroidectomy with a report of 
      adenoma of the parathyroid gland. CONCLUSION: The multicentricity of pancreatic 
      neuroendocrine tumors related to parathyroid neoplasia suggests the diagnosis of 
      MEN1. Genetic molecular studies should be performed to confirm this and provide 
      the patient with a correct diagnosis, targeted treatment and adequate genetic 
      counseling.
FAU - Gamboa-Jimenez, Tania Islem
AU  - Gamboa-Jimenez TI
FAU - Juarez-Aguilar, Fany Gabriela
AU  - Juarez-Aguilar FG
LA  - spa
PT  - Case Reports
PT  - Journal Article
TT  - Insulinoma multicentrico asociado a neoplasia endocrina multiple tipo 1: reporte 
      de un caso.
DEP - 20181025
PL  - Mexico
TA  - Rev Med Inst Mex Seguro Soc
JT  - Revista medica del Instituto Mexicano del Seguro Social
JID - 101243727
SB  - IM
MH  - Adult
MH  - Humans
MH  - Insulinoma/*diagnosis
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis
MH  - Pancreatic Neoplasms/*diagnosis
OTO - NOTNLM
OT  - *Neuroendocrine Tumors
OT  - *Insulinoma
OT  - *Multiple Endocrine Neoplasia
EDAT- 2018/11/06 06:00
MHDA- 2019/03/07 06:00
CRDT- 2018/11/06 06:00
PHST- 2018/11/06 06:00 [entrez]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
AID - http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/article/view/1526/3011 
      [pii]
PST - epublish
SO  - Rev Med Inst Mex Seguro Soc. 2018 Oct 25;56(3):316-319.