PMID- 30395303
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20200413
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 85
IP  - 6
DP  - 2019 Dec 1
TI  - Defining the Minimal Clinically Important Difference for Patients With Vestibular 
      Schwannoma: Are all Quality-of-Life Scores Significant?
PG  - 779-785
LID - 10.1093/neuros/nyy467 [doi]
AB  - BACKGROUND: The diagnosis of vestibular schwannomas (VS) is associated with 
      reduced patient quality of life (QOL). Minimal clinically important difference 
      (MCID) was introduced as the lowest improvement in a patient-reported outcome 
      (PRO) score discerned as significant by the patient. We formerly presented an 
      MCID for the Penn Acoustic Neuroma QOL (PANQOL) battery based on cross-sectional 
      data from 2 tertiary referral centers. OBJECTIVE: To validate the PANQOL MCID 
      values using prospective data. METHODS: A prospective registry capturing QOL was 
      queried, comprising patients treated at the authors' institution and Acoustic 
      Neuroma Association members. Anchor- and distribution-based techniques were 
      utilized to determine the MCID for domain and total scores. We only included 
      anchors with Spearman's correlation coefficient larger than 0.3 in the MCID 
      threshold calculations. Most domains had multiple anchors with which to estimate 
      the MCID. RESULTS: A total of 1254 patients (mean age: 57.4 yr, 65% females) were 
      analyzed. Anchor-based methods produced a span of MCID values (median, 25th-75th 
      percentile) for each PANQOL domain and the total score: hearing (13.1, 13-16 
      points), balance (14, 14-19 points), pain (21, 20-28 points), face (25, 16-36 
      points), energy (16, 15-18 points), anxiety (16 [1 estimate]), general (13 [1 
      estimate]), and total (12.5, 10-15 points). CONCLUSION: Current findings 
      corroborate our formerly shared experience using multi-institutional, 
      cross-sectional information. These MCID thresholds can serve as a pertinent 
      outcome when deciphering the clinical magnitude of VS QOL endpoints in 
      cross-sectional and longitudinal studies.
CI  - Copyright (c) 2018 by the Congress of Neurological Surgeons.
FAU - Kerezoudis, Panagiotis
AU  - Kerezoudis P
AD  - Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
FAU - Yost, Kathleen J
AU  - Yost KJ
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
FAU - Tombers, Nicole M
AU  - Tombers NM
AD  - Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Celda, Maria Peris
AU  - Celda MP
AD  - Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
FAU - Carlson, Matthew L
AU  - Carlson ML
AD  - Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
AD  - Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota.
FAU - Link, Michael J
AU  - Link MJ
AD  - Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota.
AD  - Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, 
      Minnesota.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Neuroma, Acoustic/*diagnosis/*psychology/therapy
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Registries
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acoustic neuroma
OT  - Microsurgery
OT  - Minimal clinically important difference
OT  - Observation
OT  - Patient-reported outcome measures
OT  - Quality of life
OT  - Vestibular schwannoma
EDAT- 2018/11/06 06:00
MHDA- 2020/04/14 06:00
CRDT- 2018/11/06 06:00
PHST- 2018/04/07 00:00 [received]
PHST- 2018/08/31 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2018/11/06 06:00 [entrez]
AID - 5160937 [pii]
AID - 10.1093/neuros/nyy467 [doi]
PST - ppublish
SO  - Neurosurgery. 2019 Dec 1;85(6):779-785. doi: 10.1093/neuros/nyy467.