PMID- 30396183
OWN - NLM
STAT- MEDLINE
DCOM- 20190501
LR  - 20190501
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 241
IP  - 4
DP  - 2019
TI  - Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography 
      Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma.
PG  - 195-201
LID - 10.1159/000492948 [doi]
AB  - PURPOSE: To investigate spectral domain-optical coherence tomography (SD-OCT) 
      features of untreated circumscribed choroidal hemangioma (CCH), and the optical 
      density (OD) of the associated subretinal fluid (SRF). PROCEDURES: This 
      international retrospective multicenter study conducted at 5 tertiary retina 
      referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH 
      surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. 
      RESULTS: The mean ODR of the SRF was 0.808 +/- 0.287. Tumor base measured on 
      ultrasound correlated significantly with the ODR (p = 0.012). ODR values in cases 
      of CCH were similar to those of choroidal metastasis, but significantly lower 
      than those of choroidal melanoma (p = 0.006). Thirty-two out of 34 cases (94%) 
      presented with a regular smooth choroidal surface. OCT demonstrated SRF overlying 
      the CCH in 29 eyes (85%). The presence of SRF correlated significantly with a 
      larger basal tumor diameter (p = 0.035). OCT displayed sub- and intraretinal 
      hyperreflective foci, correlating with both larger maximal retinal thickness 
      overlying the tumor (p = 0.031) and the amount of SRF (p = 0.016) in 29 eyes 
      (85%). CONCLUSION: CCH displays typical findings on SD-OCT. ODR is a new 
      important tool in the differential diagnosis of choroidal tumors and should be 
      considered for enhancing the accuracy of diagnosing CCH. This benefit is 
      especially relevant for cases in which the presentation of CCH is atypical.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Zur, Dinah
AU  - Zur D
AD  - Division of Ophthalmology, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel, 
      dinahzur@gmail.com.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 
      dinahzur@gmail.com.
FAU - Frenkel, Shahar
AU  - Frenkel S
AD  - Department of Ophthalmology, Hadassah-Hebrew University Medical Center, 
      Jerusalem, Israel.
FAU - Leshno, Ari
AU  - Leshno A
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, 
      Israel.
FAU - Iglicki, Matias
AU  - Iglicki M
AD  - Private Retina Practice, University of Buenos Aires, Buenos Aires, Argentina.
FAU - Ben-Artzi Cohen, Noa
AU  - Ben-Artzi Cohen N
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Khoury, Alla
AU  - Khoury A
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Martinez Cartier, Mauricio
AU  - Martinez Cartier M
AD  - Vision Institute, Buenos Aires, Argentina.
FAU - Barak, Adiel
AU  - Barak A
AD  - Division of Ophthalmology, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Moroz, Iris
AU  - Moroz I
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, 
      Israel.
FAU - Loewenstein, Anat
AU  - Loewenstein A
AD  - Division of Ophthalmology, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Neudorfer, Meira
AU  - Neudorfer M
AD  - Division of Ophthalmology, Tel Aviv-Sourasky Medical Center, Tel Aviv, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Vishnevskia-Dai, Vicktoria
AU  - Vishnevskia-Dai V
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, 
      Israel.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20181105
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid Neoplasms/*diagnosis
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Hemangioma/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Subretinal Fluid/*diagnostic imaging
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - Circumscribed choroidal hemangioma
OT  - Ocular tumors
OT  - Optical coherence tomography
OT  - Optical density
EDAT- 2018/11/06 06:00
MHDA- 2019/05/02 06:00
CRDT- 2018/11/06 06:00
PHST- 2018/06/04 00:00 [received]
PHST- 2018/08/15 00:00 [accepted]
PHST- 2018/11/06 06:00 [pubmed]
PHST- 2019/05/02 06:00 [medline]
PHST- 2018/11/06 06:00 [entrez]
AID - 000492948 [pii]
AID - 10.1159/000492948 [doi]
PST - ppublish
SO  - Ophthalmologica. 2019;241(4):195-201. doi: 10.1159/000492948. Epub 2018 Nov 5.