PMID- 30396264
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2093-4777 (Print)
IS  - 2093-6931 (Electronic)
IS  - 2093-4777 (Linking)
VI  - 22
IP  - Suppl 3
DP  - 2018 Oct
TI  - Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in 
      Parkinson Disease Rats.
PG  - S147-155
LID - 10.5213/inj.1836226.113 [doi]
AB  - PURPOSE: Rotenone is the most widely used neurotoxin for the making Parkinson 
      disease (PD) animal model. The neurodegenerative disorder PD shows symptoms, such 
      as slowness of movements, tremor at resting, rigidity, disturbance of gait, and 
      instability of posture. We investigated whether treadmill running improves motor 
      ability using rotenone-caused PD rats. The effect of treadmill running on PD was 
      also assessed in relation with apoptosis of cerebellar Purkinje cells. METHODS: 
      Treadmill running was applied to the rats in the exercise groups for 30 minutes 
      once a day for 4 weeks, starting 4 weeks after birth. We used rota-rod test for 
      the determination of motor coordination and balance. In this experiment, terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining, 
      immunohistochemistry for calbindin, glial fibrillary acidic protein (GFAP), 
      Iba-1, and western blot analysis for Bax and Bcl-2 were performed. RESULTS: 
      Treadmill running enhanced motor balance and coordination by preventing the loss 
      of Purkinje cells in the cerebellar vermis. Treadmill running suppressed 
      PD-induced expression of GFAP-positive reactive astrocytes and Iba-1-positive 
      microglia, showing that treadmill running suppressed reactive astrogliosis and 
      microglia activation. Treadmill running suppressed TUNEL-positive cell number and 
      Bax expression and enhanced Bcl-2 expression, demonstrating that treadmill 
      running inhibited the progress of apoptosis in the cerebellum of rotenone-induced 
      PD rats. CONCLUSION: Treadmill running improved motor ability of the 
      rotenone-induced PD rats by inhibiting apoptosis in the cerebellum. Apoptosis 
      suppressing effect of treadmill running on rotenone-induced PD was achieved via 
      suppression of reactive astrocyte and inhibition of microglial activation.
FAU - Lee, Jae-Min
AU  - Lee JM
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Kim, Tae-Woon
AU  - Kim TW
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Park, Sang-Seo
AU  - Park SS
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
FAU - Han, Jin-Hee
AU  - Han JH
AD  - Department of Anesthesiology and Pain Medicine, Kyung Hee Medical Center, College 
      of Medicine, Kyung Hee University, Seoul, Korea.
FAU - Shin, Mal-Soon
AU  - Shin MS
AD  - School of Global Sport Studies, Korea University, Sejong, Korea.
FAU - Lim, Baek-Vin
AU  - Lim BV
AD  - Division of Leisure & Sports Science, Department of Exercise Prescription, 
      Dongseo University, Busan, Korea.
FAU - Kim, Sang-Hoon
AU  - Kim SH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, Seoul, 
      Korea.
AD  - Department of Sport & Health Science, College of Natural Science, Sangmyung 
      University, Seoul, Korea.
FAU - Baek, Seung-Soo
AU  - Baek SS
AD  - Department of Sport & Health Science, College of Natural Science, Sangmyung 
      University, Seoul, Korea.
FAU - Cho, Young Sam
AU  - Cho YS
AD  - Department of Urology, Kangbuk Samsung Hospital, Sungkyunkwan University School 
      of Medicine, Seoul, Korea.
FAU - Kim, Khae Hawn
AU  - Kim KH
AD  - Department of Urology, Gil Medical Center, Gachon University School of Medicine, 
      Incheon, Korea.
LA  - eng
GR  - Astellas Pharma Korea Inc/
PT  - Journal Article
DEP - 20181031
PL  - Korea (South)
TA  - Int Neurourol J
JT  - International neurourology journal
JID - 101534513
PMC - PMC6234730
OTO - NOTNLM
OT  - Apoptosis
OT  - Motor coordination
OT  - Parkinson disease
OT  - Rotenone, Cerebellum
OT  - Treadmill exercise
COIS- Conflict of Interest KHK and YSC, associate editors of INJ, are the corresponding 
      and 9th authors of this article. However, they played no role whatsoever in the 
      editorial evaluation of this article or the decision to publish it. Except for 
      that, no potential conflict of interest relevant to this article was reported.
EDAT- 2018/11/07 06:00
MHDA- 2018/11/07 06:01
PMCR- 2018/10/01
CRDT- 2018/11/07 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2018/10/12 00:00 [accepted]
PHST- 2018/11/07 06:00 [entrez]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2018/11/07 06:01 [medline]
PHST- 2018/10/01 00:00 [pmc-release]
AID - inj.1836226.113 [pii]
AID - inj-1836226-113 [pii]
AID - 10.5213/inj.1836226.113 [doi]
PST - ppublish
SO  - Int Neurourol J. 2018 Oct;22(Suppl 3):S147-155. doi: 10.5213/inj.1836226.113. 
      Epub 2018 Oct 31.