PMID- 30396334
OWN - NLM
STAT- MEDLINE
DCOM- 20191008
LR  - 20191008
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Nov 5
TI  - Growth during the first year in infants affected by neonatal abstinence syndrome.
PG  - 343
LID - 10.1186/s12887-018-1327-0 [doi]
LID - 343
AB  - BACKGROUND: Infants with neonatal abstinence syndrome (NAS) initially experience 
      neurologic excitability, poor feeding, and/or hyperphagia in the setting of 
      increased metabolic demand. Because the longitudinal effects of these early 
      symptoms and behaviors on weight trends are unknown, we sought to contrast weight 
      gain patterns through age 1 year for infants diagnosed with NAS with matched 
      controls. METHODS: Retrospective cohort of 70 singletons with a gestational age 
      of >/=37 weeks and an ICD-9 or ICD-10 diagnosis of NAS made </=7 days after birth 
      with institutional follow-up matched to patients without NAS. Infants were 
      matched on gestational age (+/-2 weeks), birth weight (+/-20 g), sex (exact), and 
      insurance type (exact). Quantile regression methods were used to estimate 10th, 
      25th, 50th, 75th and 90th percentiles of weight over time. RESULTS: The mean 
      gestational age for an infant with NAS was 38.8 weeks (standard deviation [SD], 
      1.3). The mean birth weight was 3.141 kg (SD, 0.510). NAS patients had a median 
      of 24 weights recorded between birth and 400 days (inter-quartile range [IQR], 
      16-32 weights). Patients without NAS had a median of 12 weights recorded (IQR, 
      10-16). Growth curves were similar over the first 400 days of life. Patients with 
      NAS had non-significantly higher and lower estimated weights for the 90th and 
      10th percentiles, respectively. CONCLUSION: Infants with a diagnosis of NAS grew 
      similarly to controls during their first year. Given the frequently-encountered 
      NAS symptoms of hyperphagia and irritability, future studies may evaluate whether 
      early differences in caregiver feeding exist and whether they have longer-term 
      impacts on growth.
FAU - Corr, Tammy E
AU  - Corr TE
AUID- ORCID: 0000-0003-4169-7396
AD  - Penn State College of Medicine, Department of Pediatrics, P.O. Box 850, 500 
      University Drive, Hershey, PA, 17033-0850, USA. tcorr@pennstatehealth.psu.edu.
FAU - Schaefer, Eric W
AU  - Schaefer EW
AD  - Penn State College of Medicine, Department of Public Health Sciences, Hershey, 
      PA, USA.
FAU - Paul, Ian M
AU  - Paul IM
AD  - Penn State College of Medicine, Department of Pediatrics, P.O. Box 850, 500 
      University Drive, Hershey, PA, 17033-0850, USA.
AD  - Penn State College of Medicine, Department of Public Health Sciences, Hershey, 
      PA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181105
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Birth Weight
MH  - Case-Control Studies
MH  - Female
MH  - Gestational Age
MH  - *Growth
MH  - Growth Charts
MH  - Humans
MH  - Infant
MH  - Infant, Newborn/growth & development
MH  - Male
MH  - Neonatal Abstinence Syndrome/*physiopathology
MH  - Reference Values
MH  - Regression Analysis
MH  - Retrospective Studies
PMC - PMC6217785
OTO - NOTNLM
OT  - Behavioral feeding
OT  - Comfort feeding
OT  - Infant growth
OT  - Infant nutrition
OT  - Neonatal abstinence syndrome
OT  - Neonatal opioid withdrawal syndrome
OT  - Parenting practices
OT  - Pediatric obesity
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Approval for this study was obtained 
      by the Penn State Hershey Institutional Review Board under the reference number, 
      STUDY00005068. Because patient information was deidentified, electronic health 
      data, for the purposes of our study, consent was not obtained. CONSENT FOR 
      PUBLICATION: Not applicable. Data was collected and de-identified for the 
      purposes of analysis. COMPETING INTERESTS: The authors declare that they have no 
      competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral with 
      regard to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/11/07 06:00
MHDA- 2019/10/09 06:00
PMCR- 2018/11/05
CRDT- 2018/11/07 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/10/25 00:00 [accepted]
PHST- 2018/11/07 06:00 [entrez]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/10/09 06:00 [medline]
PHST- 2018/11/05 00:00 [pmc-release]
AID - 10.1186/s12887-018-1327-0 [pii]
AID - 1327 [pii]
AID - 10.1186/s12887-018-1327-0 [doi]
PST - epublish
SO  - BMC Pediatr. 2018 Nov 5;18(1):343. doi: 10.1186/s12887-018-1327-0.