PMID- 30397262
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20221207
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 64
IP  - 1
DP  - 2019 Jan
TI  - Interaction of MTHFR C677T polymorphism with smoking in susceptibility to 
      diabetic nephropathy in Chinese men with type 2 diabetes.
PG  - 23-28
LID - 10.1038/s10038-018-0531-y [doi]
AB  - We investigated the interaction of MTHFR C677T polymorphism (rs1801133) with 
      smoking in susceptibility to diabetic nephropathy (DN) in Chinese men with type 2 
      diabetes mellitus (T2DM). We studied 655 Chinese men with T2DM, who were divided 
      into two groups (321 with DN and 334 without DN). The genotype of MTHFR C677T 
      polymorphism was detected by real-time polymerase chain reaction. MTHFR TT 
      genotype carried a higher risk of DN compared with the CC genotype (OR = 2.05; 
      P = 0.002). The T allele showed marked association with DN development in 
      patients who smoked, using additive, recessive, and dominant models (OR = 1.60, 
      1.83, and 1.88, respectively; P = 0.006, 0.002, and 0.04, respectively), which 
      was not observed in the nonsmoking group. Patients with TT and CT genotypes, who 
      smoked had a higher risk of DN compared with the control group (non-smoking with 
      CC genotype; OR = 3.73 and 2.28, respectively; P < 0.001 and P = 0.004, 
      respectively), whereas the other groups were not observed. In conclusion, the T 
      allele of rs1801133 may be a risk factor for DN in Chinese men with T2DM, and 
      synergy appears to exist between the MTHFR rs1801133 and smoking in 
      susceptibility to DN.
FAU - Ma, Liang
AU  - Ma L
AD  - Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
FAU - Jiang, Yongwei
AU  - Jiang Y
AD  - Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
FAU - Kong, Xiaomu
AU  - Kong X
AD  - Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhao, Hailing
AU  - Zhao H
AD  - Beijing Key Laboratory of Immune-Mediated Inflammatory Diseases, Institute of 
      Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
FAU - Zhao, Tingting
AU  - Zhao T
AD  - Beijing Key Laboratory of Immune-Mediated Inflammatory Diseases, Institute of 
      Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
FAU - Cao, Yongtong
AU  - Cao Y
AD  - Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China. 
      caoyongtong92@sina.com.
FAU - Li, Ping
AU  - Li P
AD  - Beijing Key Laboratory of Immune-Mediated Inflammatory Diseases, Institute of 
      Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. 
      lp8675@163.com.
LA  - eng
PT  - Journal Article
DEP - 20181105
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diabetic Nephropathies/*epidemiology/etiology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Smoking/adverse effects/*genetics
EDAT- 2018/11/07 06:00
MHDA- 2019/03/22 06:00
CRDT- 2018/11/07 06:00
PHST- 2018/07/03 00:00 [received]
PHST- 2018/10/17 00:00 [accepted]
PHST- 2018/09/02 00:00 [revised]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
PHST- 2018/11/07 06:00 [entrez]
AID - 10.1038/s10038-018-0531-y [pii]
AID - 10.1038/s10038-018-0531-y [doi]
PST - ppublish
SO  - J Hum Genet. 2019 Jan;64(1):23-28. doi: 10.1038/s10038-018-0531-y. Epub 2018 Nov 
      5.