PMID- 30397817
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20200225
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 40
IP  - 2
DP  - 2019 Feb
TI  - Prepulse modulation and recovery of trigemino-cervical reflex in normal subjects.
PG  - 305-310
LID - 10.1007/s10072-018-3624-7 [doi]
AB  - OBJECTIVE: In this study, we analyzed the inhibitory control on the 
      trigemino-cervical reflex (TCR), and whether or not prepulse modulation (PPM) has 
      an effect on TCR. Thus, we studied the PPM of TCR. We hypothesized that TCR would 
      presumably be under the modulatory effect after the prepulse stimulus similar to 
      blink reflex (BR). We also studied the recovery of TCR which was previously 
      shown. METHODS: We included 13 healthy individuals. All subjects underwent 
      recordings of TCR, TCR-PPM, and recovery of TCR. For TCR-PPM, a subthreshold 
      stimulus to second finger 50 or 100 ms before the test stimulus was applied. For 
      recovery of TCR, two stimuli at the infraorbital nerve were applied at 300, 500, 
      and 800 ms interstimulus intervals (ISIs). RESULTS: There was an inhibition of 
      bilateral late responses of TCR at the ISIs of both 50 ms and 100 ms. There was 
      no change of latencies. Full recovery of TCR did not develop even at the ISI 
      800 ms. DISCUSSION: We have provided an evidence for the TCR-PPM in healthy 
      subjects for the first time in this study. The prepulse inhibition is attributed 
      to the functions of the pedunculopontine tegmental nucleus. Our study provides a 
      strong indication that there are connections between pedunculopontine tegmental 
      nucleus and trigemino-cervical circuit, which produces TCR.
FAU - E Kiziltan, Meral
AU  - E Kiziltan M
AD  - Department of Neurology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul, Turkey.
FAU - Bekdik Sirinocak, Pinar
AU  - Bekdik Sirinocak P
AD  - Department of Neurology, Kocaeli Derince Education and Research Hospital, 
      Istanbul, Turkey.
FAU - Akinci, Tuba
AU  - Akinci T
AD  - Department of Neurology, Beylikduzu State Hospital, Istanbul, Turkey.
FAU - Cerrahoglu Sirin, Tuba
AU  - Cerrahoglu Sirin T
AD  - Department of Neurology, Sisli Hamidiye Etfal Education and Research Hospital, 
      Istanbul, Turkey.
FAU - Arkali, Burcu Nuran
AU  - Arkali BN
AD  - Department of Neurology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul, Turkey.
FAU - Candan, Fatma
AU  - Candan F
AD  - Department of Neurology, Goztepe Education and Research Hospital, Istanbul 
      Medeniyet University, Istanbul, Turkey.
FAU - Gunduz, Aysegul
AU  - Gunduz A
AD  - Department of Neurology, Cerrahpasa School of Medicine, Istanbul 
      University-Cerrahpasa, Istanbul, Turkey. draysegulgunduz@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20181105
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Adult
MH  - Electric Stimulation
MH  - Face/physiology
MH  - Female
MH  - Fingers/physiology
MH  - *Head Movements/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pedunculopontine Tegmental Nucleus/physiology
MH  - *Prepulse Inhibition/physiology
MH  - *Reflex/physiology
MH  - Time Factors
OTO - NOTNLM
OT  - Pedunculopontine tegmental nucleus
OT  - Prepulse inhibition (PPI)
OT  - Prepulse modulation (PPM)
OT  - Recovery
OT  - Trigemino-cervical reflex (TCR)
EDAT- 2018/11/07 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/11/07 06:00
PHST- 2018/07/07 00:00 [received]
PHST- 2018/10/25 00:00 [accepted]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/11/07 06:00 [entrez]
AID - 10.1007/s10072-018-3624-7 [pii]
AID - 10.1007/s10072-018-3624-7 [doi]
PST - ppublish
SO  - Neurol Sci. 2019 Feb;40(2):305-310. doi: 10.1007/s10072-018-3624-7. Epub 2018 Nov 
      5.