PMID- 30398125
OWN - NLM
STAT- MEDLINE
DCOM- 20190618
LR  - 20190618
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Linking)
VI  - 19
IP  - 2
DP  - 2019
TI  - Leukocytoclastic Vasculitis Associated with HHV6-A/ciHHV6-A and HHV6-B 
      Coinfection in an Immunocompetent Woman.
PG  - 221-225
LID - 10.2174/1871530318666181106153758 [doi]
AB  - BACKGROUND AND OBJECTIVE: Leukocytoclastic vasculitis (LCV) is a small vessel 
      vasculitis that can be limited to the skin but may also affect other organs. 
      Often, its cause is unknown. LCV has previously been reported to occur with the 
      reactivation of human herpesvirus 6 (HHV-6). Here, we report a second instance of 
      HHV-6 reactivation in a 43-year-old woman with idiopathic cutaneous LCV. CASE 
      DESCRIPTION: In this case, the patient was immunocompetent, and testing revealed 
      that she had inherited chromosomally integrated human herpesvirus 6 variant A 
      (iciHHV6-A) with a parallel skin infection of HHV-6B. The integrated ciHHV-6A 
      strain was found to be transcriptionally active in the blood, while HHV-6B late 
      antigen was detected in a skin biopsy. The patient's rash was not accompanied by 
      fever nor systemic symptoms and resolved over four weeks without any therapeutic 
      intervention. CONCLUSION: In light of the transcriptional activity documented in 
      our case, further examination of a possible role for HHV-6 in the etiology of LCV 
      is warranted.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Calvario, Agata
AU  - Calvario A
AD  - Microbiology and Virology Unit, Policlinico University Hospital of Bari, Italy.
FAU - Foti, Caterina
AU  - Foti C
AD  - Dermatological Clinic, Department of Biomedical Science and Human Oncology, 
      University of Bari, Italy.
FAU - Scarasciulli, Maria
AU  - Scarasciulli M
AD  - Microbiology and Virology Unit, Policlinico University Hospital of Bari, Italy.
FAU - Romita, Paolo
AU  - Romita P
AD  - Dermatological Clinic, Department of Biomedical Science and Human Oncology, 
      University of Bari, Italy.
FAU - Eliassen, Eva
AU  - Eliassen E
AD  - HHV-6 Foundation, Santa Barbara, CA, United States.
FAU - Marzullo, Andrea
AU  - Marzullo A
AD  - Department of Emergency and Transplant Organ, University of Bari, Italy.
FAU - Colacicco, Anna Maria
AU  - Colacicco AM
AD  - Microbiology and Virology Unit, Policlinico University Hospital of Bari, Italy.
FAU - Miragliotta, Giuseppe
AU  - Miragliotta G
AD  - Microbiology and Virology Unit, Policlinico University Hospital of Bari, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
SB  - IM
MH  - Adult
MH  - Coinfection/complications/diagnosis/immunology/virology
MH  - Exanthema Subitum/*complications/diagnosis/immunology/virology
MH  - Female
MH  - *Herpesvirus 6, Human/classification/isolation & purification
MH  - Humans
MH  - *Immunocompetence
MH  - Roseolovirus Infections/complications/immunology/virology
MH  - Vasculitis, Leukocytoclastic, 
      Cutaneous/*complications/diagnosis/immunology/virology
OTO - NOTNLM
OT  - HHV-6
OT  - LCV
OT  - Real-Time PCR
OT  - ciHHV-6 reactivation
OT  - leukocytoclastic
OT  - vasculitis.
EDAT- 2018/11/07 06:00
MHDA- 2019/06/19 06:00
CRDT- 2018/11/07 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/09/19 00:00 [revised]
PHST- 2018/10/26 00:00 [accepted]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/06/19 06:00 [medline]
PHST- 2018/11/07 06:00 [entrez]
AID - EMIDDT-EPUB-94324 [pii]
AID - 10.2174/1871530318666181106153758 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2019;19(2):221-225. doi: 
      10.2174/1871530318666181106153758.