PMID- 30398153
OWN - NLM
STAT- MEDLINE
DCOM- 20190108
LR  - 20190108
IS  - 1952-4021 (Electronic)
IS  - 0953-1424 (Linking)
VI  - 31
IP  - 2
DP  - 2018 May 1
TI  - Ketamine and magnesium common pathway of antidepressant action.
PG  - 33-38
LID - 10.1684/mrh.2018.0440 [doi]
AB  - Depression is one of the major causes of disability worldwide. A proportion of 
      adults with major depression fail to achieve remission with first-line treatment. 
      Magnesium influences the neurotransmission involved in emotional processes, such 
      as the serotonergic, noradrenergic, dopaminergic, GABAergic and glutamatergic 
      systems. It has been reported that the mechanism of antidepressants' action is 
      involved in the glutamatergic system. Theories about the role of magnesium ions 
      in pathophysiology of major depressive disorder include blocking the 
      glutamatergic N-methyl-D-aspartate receptor (NMDAR). Ketamine, NMDAR antagonist, 
      was found to promote fast-acting antidepressant and antisuicidal effects. 
      Magnesium and ketamine seem to be involved in key mechanisms of the major 
      depression pathophysiology. The evidence in the paper discussed may indicate the 
      synergistic interaction between magnesium and ketamine pharmacodynamic activity 
      being of particular importance in mood disorders.
FAU - Gorska, Natalia
AU  - Gorska N
AD  - Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 
      Gdansk, Poland.
FAU - Cubala, Wieslaw Jerzy
AU  - Cubala WJ
AD  - Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 
      Gdansk, Poland.
FAU - Slupski, Jakub
AU  - Slupski J
AD  - Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 
      Gdansk, Poland.
FAU - Galuszko-Wegielnik, Maria
AU  - Galuszko-Wegielnik M
AD  - Department of Psychiatry, Faculty of Medicine, Medical University of Gdansk, 
      Gdansk, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Magnes Res
JT  - Magnesium research
JID - 8900948
RN  - 0 (Analgesics)
RN  - 0 (Antidepressive Agents)
RN  - 690G0D6V8H (Ketamine)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Analgesics/chemistry/*therapeutic use
MH  - Animals
MH  - Antidepressive Agents/chemistry/*therapeutic use
MH  - Depression/*drug therapy
MH  - Humans
MH  - Ketamine/chemistry/*therapeutic use
MH  - Magnesium/chemistry/*therapeutic use
OTO - NOTNLM
OT  - ketamine
OT  - magnesium
OT  - major depressive disorder
EDAT- 2018/11/07 06:00
MHDA- 2019/01/09 06:00
CRDT- 2018/11/07 06:00
PHST- 2018/11/07 06:00 [entrez]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/01/09 06:00 [medline]
AID - mrh.2018.0440 [pii]
AID - 10.1684/mrh.2018.0440 [doi]
PST - ppublish
SO  - Magnes Res. 2018 May 1;31(2):33-38. doi: 10.1684/mrh.2018.0440.