PMID- 30399148
OWN - NLM
STAT- MEDLINE
DCOM- 20190408
LR  - 20190408
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 11
DP  - 2018
TI  - Relationship between the rate of change in lamina cribrosa depth and the rate of 
      retinal nerve fiber layer thinning following glaucoma surgery.
PG  - e0206040
LID - 10.1371/journal.pone.0206040 [doi]
LID - e0206040
AB  - PURPOSE: To assess whether lamina cribrosa depth (LCD) reduction and the rate of 
      change in LCD over time (DeltaLCD/Deltat) is associated with retinal nerve fiber layer 
      (RNFL) thickness and the rate of RNFL thinning over time (DeltaRNFL/Deltat) to test the 
      hypothesis that, in a long term, RNFL thinning occurs irrespectively to the 
      displacement of the lamina cribrosa following glaucoma surgery. METHODS: 
      Twenty-nine primary open-angle glaucoma patients underwent glaucoma surgery. 
      Sixteen patients underwent trabeculectomy and 13 patients undertook 
      non-penetrating deep sclerectomy. Images of optic nerve head using 
      spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging 
      technology were obtained preoperatively, at one-, three-, six-month and follow-up 
      postoperative visit from 12 to 29 months after surgery (1pv, 3pv, 6pv, and FUpv, 
      respectively). Correspondingly, measurements of the circumpapillary RNFL 
      thickness were acquired. RESULTS: Intraocular pressure decreased from 24.0+/-8.9 to 
      10.9+/-3.9mmHg at 6pv (P<0.001) and to 12.7+/-4.4mmHg at FUpv (P<0.001). LCD was 
      reduced from 465.3+/-136.4mum to 402.9+/-126.4mum at 1pv (P<0.001) and maintained 
      similar position at 6pv (394.3+/-118.4mum; P = 0.170 with respect to 1pv). A 
      significant decrease in the LCD was noted at FUpv (342.8+/-90.3mum, P<0.001) with 
      respect to 6pv. RNFL thickness increased significantly to 64.9+/-19.8mum at 1pv (P = 
      0.005) and subsequently decreased to baseline level at 3pv. Further statistically 
      significant decrease in RNFL thickness with respect to previous visit was found 
      at 6pv and at FUpv (56.4+/-15.6mum and 55.0+/-14.0mum, P = 0.023 and P = 0.045, 
      respectively). A thinner RNFL thickness at FUpv was not related to the LCD at 
      FUpv (P = 0.129) but was correlated with DeltaLCD/Deltat at FUpv (P = 0.003). The 
      DeltaRNFL/Deltat at FUpv was statistically significantly correlated with DeltaLCD/Deltat at FUpv 
      (P<0.001). CONCLUSIONS: This is the first study that considers direct correlation 
      between the rate of change in LCD with the rate of RNFL thinning over time. A 
      thinner RNFL thickness following glaucoma surgery was associated with the rate of 
      LCD reduction, not with position of the lamina cribrosa at the FUpv.
FAU - Krzyzanowska-Berkowska, Patrycja
AU  - Krzyzanowska-Berkowska P
AUID- ORCID: 0000-0001-8034-2534
AD  - Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
FAU - Czajor, Karolina
AU  - Czajor K
AD  - Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
FAU - Helemejko, Iwona
AU  - Helemejko I
AD  - Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
FAU - Iskander, D Robert
AU  - Iskander DR
AD  - Department of Biomedical Engineering, Faculty of Fundamental Problems of 
      Technology, Wroclaw University of Science and Technology, Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181106
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Fundus Oculi
MH  - Glaucoma/*pathology/physiopathology/*surgery
MH  - Humans
MH  - Intraocular Pressure
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Nerve Fibers/*pathology
MH  - Retina/*pathology/physiopathology
MH  - Time Factors
MH  - Tomography, Optical Coherence
PMC - PMC6219770
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/11/07 06:00
MHDA- 2019/04/09 06:00
PMCR- 2018/11/06
CRDT- 2018/11/07 06:00
PHST- 2018/01/14 00:00 [received]
PHST- 2018/10/05 00:00 [accepted]
PHST- 2018/11/07 06:00 [entrez]
PHST- 2018/11/07 06:00 [pubmed]
PHST- 2019/04/09 06:00 [medline]
PHST- 2018/11/06 00:00 [pmc-release]
AID - PONE-D-18-01373 [pii]
AID - 10.1371/journal.pone.0206040 [doi]
PST - epublish
SO  - PLoS One. 2018 Nov 6;13(11):e0206040. doi: 10.1371/journal.pone.0206040. 
      eCollection 2018.