PMID- 30400047 OWN - NLM STAT- MEDLINE DCOM- 20190305 LR - 20190405 IS - 1479-683X (Electronic) IS - 0804-4643 (Linking) VI - 180 IP - 1 DP - 2019 Jan 1 TI - Early menopause and premature ovarian insufficiency are associated with increased risk of type 2 diabetes: a systematic review and meta-analysis. PG - 41-50 LID - EJE-18-0602 [pii] LID - 10.1530/EJE-18-0602 [doi] AB - Objective/Design Menopausal transition has been associated with a derangement of glucose metabolism. However, it is not known if early menopause (EM, defined as age at menopause <45 years) or premature ovarian insufficiency (POI, defined as age at menopause <40 years) are associated with increased risk of type 2 diabetes mellitus (T2DM). To systematically investigate and meta-analyze the best evidence regarding the association of age at menopause with the risk of T2DM. Methods A comprehensive search was conducted in PubMed, CENTRAL and Scopus, up to January 31, 2018. Data are expressed as odds ratio (OR) with 95% confidence intervals (CI). The I 2 index was employed for heterogeneity. Results Thirteen studies were included in the qualitative and quantitative analysis (191 762 postmenopausal women, 21 664 cases with T2DM). Both women with EM and POI were at higher risk of T2DM compared with those of age at menopause of 45-55 years (OR: 1.15, 95% CI: 1.04-1.26, P = 0.003; I 2: 61%, P < 0.002 and OR: 1.50, 95% CI: 1.03-2.19, P = 0.033; I 2: 75.2%, P < 0.003), respectively). Similar associations emerged when women with EM and POI were compared with those of age at menopause >45 years (OR: 1.12, 95% CI: 1.01-1.20, P < 0.02; I 2: 78%, P < 0.001 and OR: 1.53, 95% CI: 1.03-2.27, P = 0.035; I 2: 78%, P < 0.001), respectively). Conclusions Both EM and POI are associated with increased risk of T2DM. FAU - Anagnostis, Panagiotis AU - Anagnostis P AD - First Department of Obstetrics and Gynecology, Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Christou, Konstantinos AU - Christou K AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Artzouchaltzi, Aikaterini-Maria AU - Artzouchaltzi AM AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Gkekas, Nifon K AU - Gkekas NK AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Kosmidou, Nikoletta AU - Kosmidou N AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Siolos, Pavlos AU - Siolos P AD - Police Medical Center of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Paschou, Stavroula A AU - Paschou SA AD - Division of Endocrinology and Diabetes, 'Aghia Sophia' Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. FAU - Potoupnis, Michael AU - Potoupnis M AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - Academic Orthopaedic Unit, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece. FAU - Kenanidis, Eustathios AU - Kenanidis E AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - Academic Orthopaedic Unit, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece. FAU - Tsiridis, Eleftherios AU - Tsiridis E AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - Academic Orthopaedic Unit, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece. FAU - Lambrinoudaki, Irene AU - Lambrinoudaki I AD - Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece. FAU - Stevenson, John C AU - Stevenson JC AD - National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, UK. FAU - Goulis, Dimitrios G AU - Goulis DG AD - First Department of Obstetrics and Gynecology, Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - Centre of Orthopedic and Regenerative Medicine Research (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - England TA - Eur J Endocrinol JT - European journal of endocrinology JID - 9423848 SB - IM MH - Diabetes Mellitus, Type 2/*etiology/metabolism MH - Female MH - Humans MH - Menopause, Premature/*metabolism MH - Primary Ovarian Insufficiency/*complications MH - Risk Factors EDAT- 2018/11/08 06:00 MHDA- 2019/03/06 06:00 CRDT- 2018/11/08 06:00 PHST- 2018/07/16 00:00 [received] PHST- 2018/10/25 00:00 [accepted] PHST- 2018/11/08 06:00 [pubmed] PHST- 2019/03/06 06:00 [medline] PHST- 2018/11/08 06:00 [entrez] AID - EJE-18-0602 [pii] AID - 10.1530/EJE-18-0602 [doi] PST - ppublish SO - Eur J Endocrinol. 2019 Jan 1;180(1):41-50. doi: 10.1530/EJE-18-0602.