PMID- 30400588
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 11
DP  - 2018 Nov 5
TI  - Efficacy of Lactobacillus Administration in School-Age Children with Asthma: A 
      Randomized, Placebo-Controlled Trial.
LID - 10.3390/nu10111678 [doi]
LID - 1678
AB  - Probiotics may have immunomodulatory effects. However, these effects in asthma 
      remain unclear and warrant clinical trials. Here, we evaluated the effects of 
      Lactobacillus paracasei (LP), Lactobacillus fermentum (LF), and their combination 
      (LP + LF) on the clinical severity, immune biomarkers, and quality of life in 
      children with asthma. This double-blind, prospective, randomized, 
      placebo-controlled trial included 160 children with asthma aged 6(-)18 years (trial 
      number: NCT01635738), randomized to receive LP, LF, LP + LF, or a placebo for 3 
      months. Their Global Initiative for Asthma(-)based asthma severity, Childhood 
      Asthma Control Test (C-ACT) scores, Pediatric Asthma Severity Scores, Pediatric 
      Asthma Quality of Life Questionnaire scores, peak expiratory flow rates (PEFRs), 
      medication use, the levels of immune biomarkers (immunoglobulin E (IgE), 
      interferon gamma, interleukin 4, and tumor necrosis factor alpha) at different visits, 
      and the associated changes were evaluated. Compared with the placebo group by 
      generalized estimating equation model, children receiving LP, LF, and LP + LF had 
      lower asthma severity (p = 0.024, 0.038, and 0.007, respectively) but higher 
      C-ACT scores (p = 0.005, < 0.001, and < 0.001, respectively). The LP + LF group 
      demonstrated increased PEFR (p < 0.01) and decreased IgE levels (p < 0.05). LP, 
      LF, or their combination (LP + LF) can aid clinical improvement in children with 
      asthma.
FAU - Huang, Chian-Feng
AU  - Huang CF
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, Taipei 10055, Taiwan. davidbee416@gmail.com.
AD  - Taoyuan Psychiatric Center, Ministry of Health and Welfare, Taoyuan 33058, 
      Taiwan. davidbee416@gmail.com.
FAU - Chie, Wei-Chu
AU  - Chie WC
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, Taipei 10055, Taiwan. weichu@ntu.edu.tw.
FAU - Wang, I-Jen
AU  - Wang IJ
AUID- ORCID: 0000-0003-0091-258X
AD  - Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, No. 
      127, Su-Yuan Road, Hsin-Chuang Dist., Taipei 242, Taiwan. wij636@gmail.com.
AD  - College of Public Health, China Medical University, Taichung 40402, Taiwan. 
      wij636@gmail.com.
AD  - School of Medicine, National Yang-Ming University, Taipei 112, Taiwan. 
      wij636@gmail.com.
LA  - eng
GR  - NSC 97-2314-B-192-001-MY2/National Science Council/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181105
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Asthma/*therapy
MH  - Child
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/blood
MH  - Interleukin-4/blood
MH  - *Lactobacillus
MH  - Male
MH  - Probiotics/*administration & dosage
MH  - Prospective Studies
MH  - Quality of Life
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC6265750
OTO - NOTNLM
OT  - Childhood Asthma Control Test
OT  - Lactobacillus
OT  - asthma
OT  - immunoglobulin E
OT  - peak expiratory flow rate
OT  - probiotics
COIS- The Taipei Hospital, the Ministry of Health and Welfare Authority, has a contract 
      with GenMont Biotec Inc. whereby GenMont Biotec Inc. provided the study costs for 
      probiotics. The authors declare no conflict of interest.
EDAT- 2018/11/08 06:00
MHDA- 2019/03/21 06:00
PMCR- 2018/11/01
CRDT- 2018/11/08 06:00
PHST- 2018/09/29 00:00 [received]
PHST- 2018/10/26 00:00 [revised]
PHST- 2018/10/29 00:00 [accepted]
PHST- 2018/11/08 06:00 [entrez]
PHST- 2018/11/08 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - nu10111678 [pii]
AID - nutrients-10-01678 [pii]
AID - 10.3390/nu10111678 [doi]
PST - epublish
SO  - Nutrients. 2018 Nov 5;10(11):1678. doi: 10.3390/nu10111678.