PMID- 30401965
OWN - NLM
STAT- MEDLINE
DCOM- 20200728
LR  - 20200728
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 54
IP  - 7
DP  - 2019 Jul
TI  - Effects of HLA mismatch on cytomegalovirus reactivation in cord blood 
      transplantation.
PG  - 1004-1012
LID - 10.1038/s41409-018-0369-0 [doi]
AB  - Although human leukocyte antigen (HLA) mismatch is often thought to be associated 
      with a high incidence of cytomegalovirus (CMV) reactivation, it is not clear 
      whether this process is mediated by HLA mismatch or other factors, such as acute 
      graft-versus-host disease (aGVHD). Here we focused on cord blood transplantation 
      (CBT) and examined the effects of HLA mismatch on the incidence of CMV 
      reactivation while minimizing the effects of aGVHD. In a multivariate analysis 
      considering aGVHD as a time-dependent covariate, a significant effect on the 
      incidence of CMV reactivation was noted for HLA disparity (hazard ratio [HR]: 
      0.54 for 8/8 match compared with 3-allele mismatch) and development of aGVHD (HR: 
      1.26). Next, in an analysis excluding cases that developed aGVHD, the incidences 
      of CMV reactivation for 8/8 match and 1-allele mismatch were low compared with 
      those for other mismatches. These findings were supported by the multivariate 
      analysis (HR: 0.49 for 8/8 match and 0.64 for 1-allele mismatch compared with 
      3-allele mismatch). Together, these results suggested that HLA mismatch was 
      involved in CMV reactivation and was associated with high morbidity of 
      opportunistic infection after CBT.
FAU - Yokoyama, Hisayuki
AU  - Yokoyama H
AUID- ORCID: 0000-0001-7658-0687
AD  - Department of Hematology, Sendai Medical Center, National Hospital Organization, 
      Sendai, Japan. yokoyamah@snh.go.jp.
FAU - Kanda, Junya
AU  - Kanda J
AUID- ORCID: 0000-0002-6704-3633
AD  - Department of Hematology and Oncology, Kyoto University Graduate School of 
      Medicine, Kyoto, Japan.
FAU - Kato, Shunichi
AU  - Kato S
AD  - Department of Cell Transplantation and Regenerative Medicine, Tokai University 
      School of Medicine, Isehara, Japan.
FAU - Kondo, Eisei
AU  - Kondo E
AD  - Department of Hematology, Kawasaki Medical School, Kurashiki, Japan.
FAU - Maeda, Yoshinobu
AU  - Maeda Y
AD  - Department of Hematology and Oncology, Okayama University, Okayama, Japan.
FAU - Saji, Hiroo
AU  - Saji H
AD  - HLA Laboratory, Kyoto, Japan.
FAU - Takahashi, Satoshi
AU  - Takahashi S
AD  - Division of Molecular Therapy, The Advanced Clinical Research Center, The 
      Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
FAU - Onizuka, Makoto
AU  - Onizuka M
AD  - Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, 
      Japan.
FAU - Onishi, Yasushi
AU  - Onishi Y
AD  - Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, 
      Japan.
FAU - Ozawa, Yukiyasu
AU  - Ozawa Y
AD  - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, 
      Japan.
FAU - Kanamori, Heiwa
AU  - Kanamori H
AD  - Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Ishikawa, Jun
AU  - Ishikawa J
AD  - Department of Hematology, Osaka International Cancer Institute, Osaka, Japan.
FAU - Ohno, Yuju
AU  - Ohno Y
AD  - Department of Internal Medicine, Kitakyushu Municipal Medical Center, Kitakyushu, 
      Japan.
FAU - Ichinohe, Tatsuo
AU  - Ichinohe T
AD  - Department of Hematology and Oncology, Research Institute for Radiation Biology 
      and Medicine, Hiroshima University, Hiroshima, Japan.
FAU - Takanashi, Minoko
AU  - Takanashi M
AD  - Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
FAU - Kato, Koji
AU  - Kato K
AD  - Department of Hematology and Oncology, Children's Medical Center, Japanese Red 
      Cross Nagoya First Hospital, Nagoya, Japan.
FAU - Atsuta, Yoshiko
AU  - Atsuta Y
AD  - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
AD  - Department of Healthcare Administration, Nagoya University Graduate School of 
      Medicine, Nagoya, Japan.
FAU - Kanda, Yoshinobu
AU  - Kanda Y
AD  - Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, 
      Japan.
AD  - Division of Hematology, Department of Medicine, Jichi Medical University, 
      Shimotsuke, Japan.
CN  - HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20181106
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - *Allografts
MH  - Cord Blood Stem Cell Transplantation
MH  - Cytomegalovirus/*physiology
MH  - *Cytomegalovirus Infections/etiology/mortality
MH  - Female
MH  - *Graft vs Host Disease/etiology/mortality/virology
MH  - HLA Antigens
MH  - Hematologic Neoplasms/mortality/therapy/virology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Virus Activation
EDAT- 2018/11/08 06:00
MHDA- 2020/07/29 06:00
CRDT- 2018/11/08 06:00
PHST- 2018/07/06 00:00 [received]
PHST- 2018/10/02 00:00 [accepted]
PHST- 2018/09/28 00:00 [revised]
PHST- 2018/11/08 06:00 [pubmed]
PHST- 2020/07/29 06:00 [medline]
PHST- 2018/11/08 06:00 [entrez]
AID - 10.1038/s41409-018-0369-0 [pii]
AID - 10.1038/s41409-018-0369-0 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2019 Jul;54(7):1004-1012. doi: 10.1038/s41409-018-0369-0. 
      Epub 2018 Nov 6.