PMID- 30402225
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 9
IP  - 5
DP  - 2018 Nov
TI  - Alleviation effects of natural volatile organic compounds from Pinus densiflora 
      and Chamaecyparis obtusa on systemic and pulmonary inflammation.
PG  - 405-414
LID - 10.3892/br.2018.1147 [doi]
AB  - Chamaecyparis obtusa (C. obtusa) and Pinus densiflora (P. densiflora) have been 
      traditionally used as antibiotic, antinociceptive and anti-inflammatory agents in 
      Asian folk medicine. Recent studies have demonstrated antioxidant, 
      antiproliferative and anti-inflammatory effects of C. obtusa and P. densiflora 
      extracts. In the present study, volatile organic compounds (VOCs) of C. obtusa 
      and P. densiflora were examined to determine whether they have anti-inflammatory 
      capabilities. To evaluate the anti-inflammatory effects of VOCs of C. obtusa and 
      P. densiflora, lipopolysaccharide (LPS) was administered to the lung by nasal 
      injection and to the whole body by intraperitoneal injection. Alterations in 
      serum immunoglobulin E (IgE) levels and prostaglandin E2 (PgE2) were examined 
      using ELISA. LPS-increased serum IgE and PgE2 levels were recovered by 
      administration of dexamethasone and VOCs of C. obtusa and P. densiflora. Levels 
      of mRNA expression of inflammatory cytokines were determined in an LPS-induced 
      inflammation mouse model. Reverse transcription-quantitative polymerase chain 
      reaction was used to determine the mRNA expression levels of cyclooxygenase 2, 
      interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-13 in peripheral blood 
      mononuclear cells. The expression of all examined cytokine mRNAs increased by LPS 
      was suppressed by dexamethasone and VOCs of C. obtusa and P. densiflora. Similar 
      tendencies were observed in lung tissues and cells obtained via bronchoalveolar 
      lavage. The results of the present study suggested that VOCs of C. obtusa and P. 
      densiflora, through their immunosuppressive activities, may have therapeutic 
      potential in the treatment or prevention of inflammation.
FAU - Ahn, Changhwan
AU  - Ahn C
AD  - Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical 
      Center and College of Veterinary Medicine, Chungbuk National University, 
      Cheongju, Chungbuk 28644, Republic of Korea.
FAU - Lee, Jae-Hwan
AU  - Lee JH
AD  - Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical 
      Center and College of Veterinary Medicine, Chungbuk National University, 
      Cheongju, Chungbuk 28644, Republic of Korea.
FAU - Kim, Jae-Woo
AU  - Kim JW
AD  - Division of Wood Chemistry and Microbiology, Department of Forest Products, 
      National Institute of Forest Science, Seoul 02455, Republic of Korea.
FAU - Park, Mi-Jin
AU  - Park MJ
AD  - Division of Wood Chemistry and Microbiology, Department of Forest Products, 
      National Institute of Forest Science, Seoul 02455, Republic of Korea.
FAU - Lee, Sung-Suk
AU  - Lee SS
AD  - Division of Wood Chemistry and Microbiology, Department of Forest Products, 
      National Institute of Forest Science, Seoul 02455, Republic of Korea.
FAU - Jeung, Eui-Bae
AU  - Jeung EB
AD  - Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical 
      Center and College of Veterinary Medicine, Chungbuk National University, 
      Cheongju, Chungbuk 28644, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180912
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC6200960
OTO - NOTNLM
OT  - Chamaecyparis obtusa
OT  - Pinus densiflora
OT  - cytokine
OT  - inflammation
OT  - lung
EDAT- 2018/11/08 06:00
MHDA- 2018/11/08 06:01
PMCR- 2018/09/12
CRDT- 2018/11/08 06:00
PHST- 2018/03/26 00:00 [received]
PHST- 2018/09/06 00:00 [accepted]
PHST- 2018/11/08 06:00 [entrez]
PHST- 2018/11/08 06:00 [pubmed]
PHST- 2018/11/08 06:01 [medline]
PHST- 2018/09/12 00:00 [pmc-release]
AID - BR-0-0-1147 [pii]
AID - 10.3892/br.2018.1147 [doi]
PST - ppublish
SO  - Biomed Rep. 2018 Nov;9(5):405-414. doi: 10.3892/br.2018.1147. Epub 2018 Sep 12.