PMID- 3040286
OWN - NLM
STAT- MEDLINE
DCOM- 19871002
LR  - 20190828
IS  - 0344-5704 (Print)
IS  - 0344-5704 (Linking)
VI  - 20
IP  - 1
DP  - 1987
TI  - Elevation of plasma levels of fluorinated pyrimidines by guanosine 
      5'-monophosphate.
PG  - 1-4
AB  - The plasma concentration of 5-fluorouracil (FUra) following the i.v. 
      administration of FUra and guanosine 5'-monophosphate (GMP) or guanosine 
      5'-triphosphate (GTP) was markedly elevated. These values were more than 5-fold 
      higher than those obtained with FUra alone over 60 min after administration. The 
      elevation of plasma levels corresponded to the dose of GMP. Higher levels of FUra 
      were maintained in the plasma after injection of inosine or inosine 
      5'-monophosphate in combination with FUra than after FUra alone, but they were 
      lower than those induced by GMP or GTP. Moreover, plasma levels of two other 
      fluorinated pyrimidines, 5'-deoxy-5-fluorouridine (DFUR) and 
      5-fluoro-2'-deoxycytidine (FdCyd), were also elevated by GMP. The combination of 
      DFUR and GMP resulted in higher plasma levels of DFUR itself and FUra (12- and 
      10-fold, respectively, 30 min after treatment). After administration of FdCyd 
      plus GMP, the plasma levels of FdCyd, 5-fluoro-2'-deoxyuridine, which is 
      converted from FdCyd by cytidine deaminase, and FUra were 2-, 6-, and 7-fold 
      higher, respectively, than those after FdCyd alone 30 min after treatment. Thus, 
      GMP is the most effective compound for the maintenance of high plasma levels of 
      fluorinated pyrimidines.
FAU - Iigo, M
AU  - Iigo M
FAU - Yamaizumi, Z
AU  - Yamaizumi Z
FAU - Nishimura, S
AU  - Nishimura S
FAU - Hoshi, A
AU  - Hoshi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Cancer Chemother Pharmacol
JT  - Cancer chemotherapy and pharmacology
JID - 7806519
RN  - 0 (Guanine Nucleotides)
RN  - 039LU44I5M (Floxuridine)
RN  - 0W860991D6 (Deoxycytidine)
RN  - 131-99-7 (Inosine Monophosphate)
RN  - 85-32-5 (Guanosine Monophosphate)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - KUA4693H5W (5-fluoro-2'-deoxycytidine)
RN  - U3P01618RT (Fluorouracil)
RN  - V1JK16Y2JP (doxifluridine)
SB  - IM
MH  - Animals
MH  - Deoxycytidine/analogs & derivatives/blood
MH  - Drug Interactions
MH  - Floxuridine/blood
MH  - Fluorouracil/*blood
MH  - Guanine Nucleotides/*pharmacology
MH  - Guanosine Monophosphate/*pharmacology
MH  - Guanosine Triphosphate/pharmacology
MH  - Inosine Monophosphate/pharmacology
MH  - Male
MH  - Mice
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1007/BF00252949 [doi]
PST - ppublish
SO  - Cancer Chemother Pharmacol. 1987;20(1):1-4. doi: 10.1007/BF00252949.