PMID- 30403195
OWN - NLM
STAT- MEDLINE
DCOM- 20190822
LR  - 20190822
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 63
IP  - 22
DP  - 2018 Nov 7
TI  - Exogenous imaging contrast and therapeutic agents for intravascular photoacoustic 
      imaging and image-guided therapy.
PG  - 22TR01
LID - 10.1088/1361-6560/aae62b [doi]
AB  - Intravascular photoacoustic (IVPA) imaging has been developed in recent years as 
      a viable imaging modality for the assessment of atherosclerotic plaques. 
      Exogenous imaging contrast and therapeutic agents further enhance this imaging 
      modality and provide significant benefits. Imaging contrast agents can 
      significantly increase photoacoustic signal, resulting in enhanced plaque 
      detection and characterization. The ability to use these particles to molecularly 
      target markers of disease progression makes it possible to determine 
      patient-specific levels of risk and plan treatments accordingly. With improved 
      diagnosis, clinicians will be able to use therapeutic agents that are synergistic 
      with IVPA imaging to treat atherosclerotic patients. Pre-clinical and clinical 
      studies with relevance to IVPA imaging have shown promise in the area of 
      diagnosis and therapeutics. In this review, we present a variety of imaging 
      contrast agents that are either designed for or are compatible with IVPA imaging, 
      cover uses of therapeutic agents that compliment this imaging modality, and 
      discuss future directions of research in the field.
FAU - Sowers, Timothy
AU  - Sowers T
AD  - Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of 
      Technology, Atlanta, GA, United States of America. George W. Woodruff School of 
      Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, United 
      States of America.
FAU - Emelianov, Stanislav
AU  - Emelianov S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20181107
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
RN  - 0 (Contrast Media)
MH  - Contrast Media/*adverse effects
MH  - Humans
MH  - Photoacoustic Techniques/*methods
MH  - Plaque, Atherosclerotic/*diagnostic imaging
MH  - Ultrasonography, Interventional/*methods
EDAT- 2018/11/08 06:00
MHDA- 2019/08/23 06:00
CRDT- 2018/11/08 06:00
PHST- 2018/11/08 06:00 [entrez]
PHST- 2018/11/08 06:00 [pubmed]
PHST- 2019/08/23 06:00 [medline]
AID - 10.1088/1361-6560/aae62b [doi]
PST - epublish
SO  - Phys Med Biol. 2018 Nov 7;63(22):22TR01. doi: 10.1088/1361-6560/aae62b.