PMID- 30403441
OWN - NLM
STAT- MEDLINE
DCOM- 20200417
LR  - 20210109
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 24
IP  - 2
DP  - 2019 Mar
TI  - Electrocardiographic predictors of myocardial fibrosis and apical hypertrophic 
      cardiomyopathy.
PG  - e12612
LID - 10.1111/anec.12612 [doi]
LID - e12612
AB  - BACKGROUND: Electrocardiography (ECG) may be an efficacious diagnostic and 
      prognostic tool in hypertrophic cardiomyopathy (HCM). This study aimed to 
      investigate association between deep T-wave inversion (TWI) and apical HCM, and 
      between fragmented QRS (fQRS) complex and myocardial fibrosis in patients with 
      HCM. METHODS: Patients with documented HCM by cardiac magnetic resonance imaging 
      (CMR) during 2005-2015 were studied. The 12-lead ECG and CMR were performed on 
      the same day. All patients underwent CMR for the assessment of cardiac structure, 
      function, and late gadolinium enhancement (LGE). LGE was used to detect 
      myocardial fibrosis. RESULTS: One hundred forty-four HCM (mean age 
      66 +/- 15.8 years, 60.4% male) were included. Twenty-nine (20.14%) subjects had 
      deep TWI, and apical HCM was found in 76 (52.78%). Deep TWI was associated with 
      apical HCM with the Odds ratio (95%CI) of 5.82 (2.07, 16.04) and p < 0.001 in 
      univariate analysis model. The association was still significant in multivariate 
      analysis with adjusted Odds ratio (95%CI) of 9.86 (3.17, 30.66), p < 0.001. 
      Forty-seven (32.64%) subjects had fQRS complex, and myocardial fibrosis was 
      detected in 101 (70.14%). fQRS complex was found to be associated with myocardial 
      fibrosis in univariate analysis with the Odds ratio (95%CI) = 2.75 (1.16, 6.54), 
      p = 0.019. However, the association cannot be demonstrated in the multivariate 
      analysis. CONCLUSION: Deep TWI is independently associated with apical HCM, but 
      the relationship between fQRS complex and myocardial fibrosis did not survive 
      multivariate analysis.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Tangwiwat, Chayapat
AU  - Tangwiwat C
AD  - Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Kaolawanich, Yodying
AU  - Kaolawanich Y
AD  - Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Krittayaphong, Rungroj
AU  - Krittayaphong R
AUID- ORCID: 0000-0001-8684-2361
AD  - Division of Cardiology, Department of Medicine, Faculty of Medicine Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20181107
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*epidemiology/pathology
MH  - Cohort Studies
MH  - Comorbidity
MH  - Electrocardiography/*methods
MH  - Female
MH  - Fibrosis/diagnostic imaging/epidemiology/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Survival Rate
MH  - Thailand/epidemiology
PMC - PMC6931658
OTO - NOTNLM
OT  - ECG
OT  - apical hypertrophic cardiomyopathy
OT  - electrocardiographic predictors
OT  - myocardial fibrosis
COIS- Both authors declare no personal or professional conflict of interests, and no 
      financial support from the companies that produce and/or distribute the drugs, 
      devices, or materials described in this report.
EDAT- 2018/11/08 06:00
MHDA- 2020/04/18 06:00
PMCR- 2018/11/07
CRDT- 2018/11/08 06:00
PHST- 2018/08/04 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/10/12 00:00 [accepted]
PHST- 2018/11/08 06:00 [pubmed]
PHST- 2020/04/18 06:00 [medline]
PHST- 2018/11/08 06:00 [entrez]
PHST- 2018/11/07 00:00 [pmc-release]
AID - ANEC12612 [pii]
AID - 10.1111/anec.12612 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2019 Mar;24(2):e12612. doi: 10.1111/anec.12612. 
      Epub 2018 Nov 7.