PMID- 3040461
OWN - NLM
STAT- MEDLINE
DCOM- 19871015
LR  - 20190722
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 97
IP  - 3
DP  - 1987 Sep
TI  - CCK-8 elicits grooming: cross tolerance to ACTH1-24.
PG  - 697-703
AB  - Rats received lateral intracerebroventricular (icv) injection of sulfated or 
      desulfated cholecystokinin octapeptide (CCK-8-S or CCK-8-D, respectively) and 
      subsequent grooming behaviors were observed using a behavioral sampling 
      technique. CCK-8-S (2.0 to 4.0 micrograms in 10 microliter) elicited a 
      significant increase in grooming behaviors relative to the controls, but the 
      relatively inactive CCK-8-D did not. Excessive grooming induced by CCK-8-S 
      produced less grooming than did the adrenocorticotropic hormone fragment, 
      ACTH1-24 (1.0 microgram in 10 microliter). An icv injection of CCK-8-S 3 h before 
      the icv injection of ACTH1-24 inhibited the usual excessive grooming produced by 
      the ACTH. Conversely, prior injection of ACTH1-24 abolished the increased 
      grooming induced by CCK-8-S. Thus, the sulfated cholecystokinin octapeptide and 
      ACTH1-24 exhibited short-term cross tolerance for excessive grooming. These 
      results suggest that the colocalization of corticotropin releasing hormone and 
      CCK-8 in neurons may have functional significance in connection with 
      stress-related neuronal systems.
FAU - Kulkosky, P J
AU  - Kulkosky PJ
FAU - Molello, C L
AU  - Molello CL
FAU - Isaacson, R L
AU  - Isaacson RL
LA  - eng
GR  - RR-08197-05/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 16960-16-0 (Cosyntropin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - M03GIQ7Z6P (Sincalide)
SB  - IM
MH  - Adrenocorticotropic Hormone/*pharmacology
MH  - Animals
MH  - Cosyntropin/*pharmacology
MH  - Grooming/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sincalide/*pharmacology
EDAT- 1987/09/01 00:00
MHDA- 1987/09/01 00:01
CRDT- 1987/09/01 00:00
PHST- 1987/09/01 00:00 [pubmed]
PHST- 1987/09/01 00:01 [medline]
PHST- 1987/09/01 00:00 [entrez]
AID - 10.1016/0014-4886(87)90126-9 [doi]
PST - ppublish
SO  - Exp Neurol. 1987 Sep;97(3):697-703. doi: 10.1016/0014-4886(87)90126-9.