PMID- 30405022
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 11
DP  - 2018 Nov 7
TI  - A Pilot Clinical Study of Liquid Ubiquinol Supplementation on Cardiac Function in 
      Pediatric Dilated Cardiomyopathy.
LID - 10.3390/nu10111697 [doi]
LID - 1697
AB  - BACKGROUND: Pediatric dilated cardiomyopathy (PDCM) is a life-threatening type of 
      cardiac muscle dysfunction in children. Ubiquinone is a lipid-soluble nutrient 
      that participates in energy synthesis. Recently, a novel hydrophilic ubiquinol 
      supplement was developed. The purpose of this study was to assess the effect of 
      liquid ubiquinol supplementation (10 mg/kg body weight/day) on cardiac function 
      in children with PDCM. METHODS: Ten children diagnosed with PDCM were recruited 
      to this study and administered with liquid ubiquinol for 24 weeks. The cardiac 
      function was measured by echocardiography. The New York Heart Association (NYHA) 
      functional classification was used to assess symptoms of heart failure. Plasma 
      coenzyme Q10 levels were measured during the study. RESULTS: Ejection fraction 
      (EF) and fractional shortening (FS) were significantly higher than the baseline 
      values until week 16 of supplementation. Subjects who had higher plasma coenzyme 
      Q10 concentration had significantly better EF and FS values. In addition, 30% of 
      the subjects showed improvement in the NYHA classification after 24 weeks of 
      supplementation. CONCLUSION: Liquid ubiquinol supplementation is associated with 
      an increase the level of coenzyme Q10 to complementary improve cardiac function 
      (particularly EF and FS) and ameliorate the symptoms of heart failure in children 
      with PDCM.
FAU - Chen, Fong-Lin
AU  - Chen FL
AD  - Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, 
      Taiwan. cshy053@gmail.com.
AD  - School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan. 
      cshy053@gmail.com.
AD  - Pediatric Cardiology Clinic, Taichung 40244, Taiwan. cshy053@gmail.com.
FAU - Chang, Po-Sheng
AU  - Chang PS
AD  - Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. 
      ccrazybon@gmail.com.
AD  - Graduate Program in Nutrition, Chung Shan Medical University, Taichung 40201, 
      Taiwan. ccrazybon@gmail.com.
FAU - Lin, Yi-Chin
AU  - Lin YC
AD  - Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. 
      ymlin@csmu.edu.tw.
FAU - Lin, Ping-Ting
AU  - Lin PT
AUID- ORCID: 0000-0002-4271-3928
AD  - Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan. 
      apt810@csmu.edu.tw.
AD  - Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, 
      Taiwan. apt810@csmu.edu.tw.
LA  - eng
GR  - MOST 105-2628-B-040-004-MY2 and MOST 107-2320-B-040-0011/Ministry of Science and 
      Technology, Taiwan/
PT  - Clinical Study
PT  - Journal Article
DEP - 20181107
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - M9NL0C577Y (ubiquinol)
SB  - IM
MH  - Adolescent
MH  - Anthropometry
MH  - Cardiomyopathy, Dilated/blood/*drug therapy
MH  - Child
MH  - Child, Preschool
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Ubiquinone/administration & dosage/*analogs & derivatives/blood
PMC - PMC6266971
OTO - NOTNLM
OT  - coenzyme Q10
OT  - dietary supplementation
OT  - heart failure
OT  - liquid ubiquinol
OT  - pediatric dilated cardiomyopathy
OT  - pediatric nutrition
COIS- The authors have no conflict of interest.
EDAT- 2018/11/09 06:00
MHDA- 2019/03/06 06:00
PMCR- 2018/11/01
CRDT- 2018/11/09 06:00
PHST- 2018/09/29 00:00 [received]
PHST- 2018/10/25 00:00 [revised]
PHST- 2018/11/05 00:00 [accepted]
PHST- 2018/11/09 06:00 [entrez]
PHST- 2018/11/09 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2018/11/01 00:00 [pmc-release]
AID - nu10111697 [pii]
AID - nutrients-10-01697 [pii]
AID - 10.3390/nu10111697 [doi]
PST - epublish
SO  - Nutrients. 2018 Nov 7;10(11):1697. doi: 10.3390/nu10111697.