PMID- 30405361
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20231004
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 12
DP  - 2018
TI  - The Influence of a Memory Delay on Spatial Coding in the Superior Colliculus: Is 
      Visual Always Visual and Motor Always Motor?
PG  - 74
LID - 10.3389/fncir.2018.00074 [doi]
LID - 74
AB  - The memory-delay saccade task is often used to separate visual and motor 
      responses in oculomotor structures such as the superior colliculus (SC), with the 
      assumption that these same responses would sum with a short delay during 
      immediate "reactive" saccades to visual stimuli. However, it is also possible 
      that additional signals (suppression, delay) alter visual and/or motor response 
      in the memory delay task. Here, we compared the spatiotemporal properties of 
      visual and motor responses of the same SC neurons recorded during both the 
      reactive and memory-delay tasks in two head-unrestrained monkeys. Comparing 
      tasks, visual (aligned with target onset) and motor (aligned on saccade onset) 
      responses were highly correlated across neurons, but the peak response of visual 
      neurons and peak motor responses (of both visuomotor (VM) and motor neurons) were 
      significantly higher in the reactive task. Receptive field organization was 
      generally similar in both tasks. Spatial coding (along a Target-Gaze (TG) 
      continuum) was also similar, with the exception that pure motor cells showed a 
      stronger tendency to code future gaze location in the memory delay task, 
      suggesting a more complete transformation. These results suggest that the 
      introduction of a trained memory delay alters both the vigor and spatial coding 
      of SC visual and motor responses, likely due to a combination of saccade 
      suppression signals and greater signal noise accumulation during the delay in the 
      memory delay task.
FAU - Sadeh, Morteza
AU  - Sadeh M
AD  - York Centre for Vision Research, York University, Toronto, ON, Canada.
AD  - Vision: Science to Applications (VISTA) Program, York University, Toronto, ON, 
      Canada.
AD  - York Neuroscience Graduate Diploma Program, York University, Toronto, ON, Canada.
AD  - Canadian Action and Perception Network (CAPnet), York University, Toronto, ON, 
      Canada.
AD  - Departments of Psychology, Biology and Kinesiology and Health Science, York 
      University, Toronto, ON, Canada.
FAU - Sajad, Amirsaman
AU  - Sajad A
AD  - York Centre for Vision Research, York University, Toronto, ON, Canada.
AD  - York Neuroscience Graduate Diploma Program, York University, Toronto, ON, Canada.
AD  - Canadian Action and Perception Network (CAPnet), York University, Toronto, ON, 
      Canada.
AD  - Departments of Psychology, Biology and Kinesiology and Health Science, York 
      University, Toronto, ON, Canada.
FAU - Wang, Hongying
AU  - Wang H
AD  - York Centre for Vision Research, York University, Toronto, ON, Canada.
AD  - Vision: Science to Applications (VISTA) Program, York University, Toronto, ON, 
      Canada.
FAU - Yan, Xiaogang
AU  - Yan X
AD  - York Centre for Vision Research, York University, Toronto, ON, Canada.
AD  - Vision: Science to Applications (VISTA) Program, York University, Toronto, ON, 
      Canada.
FAU - Crawford, John Douglas
AU  - Crawford JD
AD  - York Centre for Vision Research, York University, Toronto, ON, Canada.
AD  - Vision: Science to Applications (VISTA) Program, York University, Toronto, ON, 
      Canada.
AD  - York Neuroscience Graduate Diploma Program, York University, Toronto, ON, Canada.
AD  - Canadian Action and Perception Network (CAPnet), York University, Toronto, ON, 
      Canada.
AD  - Departments of Psychology, Biology and Kinesiology and Health Science, York 
      University, Toronto, ON, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181022
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
SB  - IM
MH  - Animals
MH  - Eye Movements/physiology
MH  - Female
MH  - Macaca mulatta
MH  - Memory/*physiology
MH  - Motor Neurons/*physiology
MH  - Photic Stimulation/*methods
MH  - Reaction Time/*physiology
MH  - Superior Colliculi/*physiology
MH  - Visual Pathways/physiology
MH  - Visual Perception/*physiology
PMC - PMC6204359
OTO - NOTNLM
OT  - gaze shift
OT  - memory
OT  - primates
OT  - saccades
OT  - superior colliculi
EDAT- 2018/11/09 06:00
MHDA- 2019/03/26 06:00
PMCR- 2018/01/01
CRDT- 2018/11/09 06:00
PHST- 2018/05/06 00:00 [received]
PHST- 2018/08/29 00:00 [accepted]
PHST- 2018/11/09 06:00 [entrez]
PHST- 2018/11/09 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2018.00074 [doi]
PST - epublish
SO  - Front Neural Circuits. 2018 Oct 22;12:74. doi: 10.3389/fncir.2018.00074. 
      eCollection 2018.