PMID- 30405737 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220409 IS - 1741-427X (Print) IS - 1741-4288 (Electronic) IS - 1741-427X (Linking) VI - 2018 DP - 2018 TI - The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex. PG - 3052058 LID - 10.1155/2018/3052058 [doi] LID - 3052058 AB - Rehmanniae radix preparata is extracted from wine-steaming the Rehmannia root, a scrophulariaceae plant. It has been used for thousands of years with effects of nourishing kidney-yin, benefiting essence and filling marrow based on traditional Chinese medicine (TCM) theory. Rehmanniae radix preparata has antioxidant, antisenescence, anti-inflammatory, and neuroprotective properties. It is the most popular Traditional Chinese medicinal compound (TCMC) used in attention deficit hyperactivity disorder (ADHD) therapy. However, few studies have been conducted exploring the effects and potential mechanisms of Rehmanniae radix preparata alone on ADHD. Recent studies have shown that Rehmanniae radix preparata inhibits spontaneous activity in mice, improves learning and memory in rats following thalamic arcuate nucleus injury, and exhibits antidepressant effects. Catalpol, an active component of Rehmanniae radix preparata, elevates brain-derived neurotrophic factor (BDNF), and attenuates neuronal apoptosis and energy metabolism failure. ADHD is characterized by hyperactivity-impulsivity and impairments in learning and memory. Its pathomechanism is closely related to structural abnormalities in the cortex that is mediated by dysfunction in neuronal development, apoptosis, and energy metabolism. We hypothesize that Rehmanniae radix preparata may be effective at treating ADHD by alleviating neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failure. FAU - Yuan, Haixia AU - Yuan H AD - Nanjing University of Chinese Medicine, First Clinical Medical College, Institute of Pediatrics of traditional Chinese Medicine, Qixia District, Nanjing, 210029, Jiangsu Province, China. FAU - Yang, Meng AU - Yang M AD - Nanjing University of Chinese Medicine, Institute of Chinese medicine literature, Qixia District, Nanjing, 210029, Jiangsu Province, China. FAU - Han, Xinmin AU - Han X AUID- ORCID: 0000-0001-8935-8997 AD - Nanjing University of Chinese Medicine, First Clinical Medical College, Institute of Pediatrics of traditional Chinese Medicine, Qixia District, Nanjing, 210029, Jiangsu Province, China. FAU - Ni, Xinqiang AU - Ni X AUID- ORCID: 0000-0002-0543-6482 AD - Shenzhen traditional Chinese Medicine Hospital, Pediatrics of traditional Chinese Medicine, Shenzhen, 518038, Guangdong Province, China. AD - Institute of Geriatrics, Shenzhen, 518035, Guangdong Province, China. LA - eng PT - Journal Article PT - Review DEP - 20181014 PL - United States TA - Evid Based Complement Alternat Med JT - Evidence-based complementary and alternative medicine : eCAM JID - 101215021 PMC - PMC6204205 EDAT- 2018/11/09 06:00 MHDA- 2018/11/09 06:01 PMCR- 2018/10/14 CRDT- 2018/11/09 06:00 PHST- 2018/06/15 00:00 [received] PHST- 2018/09/02 00:00 [revised] PHST- 2018/09/10 00:00 [accepted] PHST- 2018/11/09 06:00 [entrez] PHST- 2018/11/09 06:00 [pubmed] PHST- 2018/11/09 06:01 [medline] PHST- 2018/10/14 00:00 [pmc-release] AID - 10.1155/2018/3052058 [doi] PST - epublish SO - Evid Based Complement Alternat Med. 2018 Oct 14;2018:3052058. doi: 10.1155/2018/3052058. eCollection 2018.