PMID- 30409390 OWN - NLM STAT- MEDLINE DCOM- 20190829 LR - 20191101 IS - 2451-9030 (Electronic) IS - 2451-9022 (Linking) VI - 3 IP - 11 DP - 2018 Nov TI - Anhedonia in Trauma-Exposed Individuals: Functional Connectivity and Decision-Making Correlates. PG - 959-967 LID - S2451-9022(17)30200-8 [pii] LID - 10.1016/j.bpsc.2017.10.008 [doi] AB - BACKGROUND: Reward processing deficits have been increasingly associated with trauma exposure and are a core feature of posttraumatic stress disorder (PTSD). While altered resting-state functional connectivity (rsFC) of ventral striatal regions, including the nucleus accumbens (NAcc), has been associated with anhedonia in some stress-related disorders, relationships between NAcc rsFC and anhedonia have not previously been investigated in trauma-exposed individuals. Additionally, relationships between anhedonia and reward-related decision making remain unexplored in relation to trauma exposure. We hypothesized that elevated anhedonia would be associated with altered rsFC between NAcc and default mode network regions and with increased delay discounting. METHODS: The sample included 51 participants exposed to a DSM-IV PTSD Criterion A event related to community trauma. Participants completed the Clinician Administered PTSD Scale, the Snaith-Hamilton Pleasure Scale, the Beck Depression Inventory, a computerized delay discounting paradigm, and resting-state functional magnetic resonance imaging. rsFC data were analyzed in SPM12 and CONN. RESULTS: Higher levels of anhedonia were associated with increased rsFC between seed regions of bilateral NAcc and areas of right dorsomedial prefrontal cortex. This relationship remained significant after accounting for Clinician Administered PTSD Scale total scores, Beck Depression Inventory total scores, or diagnostic group in the regression. Additionally, anhedonia was associated with elevated (increased) delay discounting. CONCLUSIONS: Greater anhedonia was related to higher positive connectivity between NAcc and right dorsomedial prefrontal cortex and to increased delay discounting, i.e., greater preference for smaller immediate versus larger delayed rewards. These findings contribute to a growing body of literature emphasizing the importance of anhedonia in trauma-exposed individuals. CI - Copyright (c) 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. FAU - Olson, Elizabeth A AU - Olson EA AD - Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. Electronic address: eaolson@mclean.harvard.edu. FAU - Kaiser, Roselinde H AU - Kaiser RH AD - Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Department of Psychology, University of California Los Angeles, Los Angeles, California. FAU - Pizzagalli, Diego A AU - Pizzagalli DA AD - Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont; McLean Imaging Center, McLean Hospital, Belmont; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. FAU - Rauch, Scott L AU - Rauch SL AD - Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. FAU - Rosso, Isabelle M AU - Rosso IM AD - Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. LA - eng GR - K23 MH112873/MH/NIMH NIH HHS/United States GR - R01 MH095809/MH/NIMH NIH HHS/United States GR - R01 MH096987/MH/NIMH NIH HHS/United States GR - R37 MH068376/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20171116 PL - United States TA - Biol Psychiatry Cogn Neurosci Neuroimaging JT - Biological psychiatry. Cognitive neuroscience and neuroimaging JID - 101671285 SB - IM MH - Adult MH - Anhedonia/*physiology MH - Brain/*physiopathology MH - Decision Making/*physiology MH - Depressive Disorder, Major/physiopathology MH - Female MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Neural Pathways/*physiopathology MH - Reward MH - Stress Disorders, Post-Traumatic/physiopathology MH - Young Adult PMC - PMC6233731 MID - NIHMS921779 OTO - NOTNLM OT - Anhedonia OT - Delay discounting OT - Functional connectivity OT - Posttraumatic stress disorder OT - Resting state OT - Reward COIS- FINANCIAL DISCLOSURES Conflicts of interest: All authors declare no biomedical financial interests or potential conflicts of interest related to the present work. EAO reports receiving research funding from the Brain & Behavior Research Foundation and from McLean Hospital. RHK reports receiving research funding from the Brain & Behavior Research Foundation, from McLean Hospital, and from University of California Los Angeles. DAP reports receiving research funding from the National Institute of Mental Health and the Dana Foundation. Over the past two years, he has received consulting fees from Akili Interactive Labs, BlackThorn Therapeutics, Boehringer Ingelheim, and Posit Science for activities unrelated to the present work. SLR reports receiving research funding from NIMH and The US Army. He is employed by McLean Hospital/Partners Healthcare. He also serves on a VA Research Advisory Committee on Gulf War Illness. He provides unpaid Board service for a number of non-profit organizations, including SOBP, ADAA, and Project 375. He receives royalty payments from Oxford University Press. He has also received honoraria for lectures and/or consultations from various academic institutions including Harvard University, Brown University, Columbia University, University of Miami, and University of Cincinnati as well as CAMH in Toronto. IMR reports receiving research funding from NIMH and the Brain & Behavior Research Foundation. EDAT- 2018/11/10 06:00 MHDA- 2019/08/30 06:00 PMCR- 2019/11/01 CRDT- 2018/11/10 06:00 PHST- 2017/07/07 00:00 [received] PHST- 2017/10/28 00:00 [revised] PHST- 2017/10/30 00:00 [accepted] PHST- 2018/11/10 06:00 [entrez] PHST- 2018/11/10 06:00 [pubmed] PHST- 2019/08/30 06:00 [medline] PHST- 2019/11/01 00:00 [pmc-release] AID - S2451-9022(17)30200-8 [pii] AID - 10.1016/j.bpsc.2017.10.008 [doi] PST - ppublish SO - Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Nov;3(11):959-967. doi: 10.1016/j.bpsc.2017.10.008. Epub 2017 Nov 16.