PMID- 30411316
OWN - NLM
STAT- MEDLINE
DCOM- 20200508
LR  - 20200508
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 63
IP  - 4
DP  - 2019 Apr
TI  - Supervised exercise training with multimodal pre-habilitation leads to earlier 
      functional recovery following colorectal cancer resection.
PG  - 461-467
LID - 10.1111/aas.13292 [doi]
AB  - BACKGROUND: Exercise training is a component of the pre-habilitation program. 
      While in one previous study the training was home-based, in a subsequent 
      investigation it was supervised in hospital. The hypothesis of this secondary 
      analysis of the two studies was to determine whether supervised exercise further 
      accelerates the return to baseline walking ability. METHODS: Data from two 
      consecutive randomized control trials (RCT) comparing pre-habilitation to the 
      rehabilitation of cancer patients scheduled for colorectal surgery were pooled 
      for analysis. The interventions were similar and included home-based exercise 
      training, nutritional counseling and protein supplementation, and relaxation 
      techniques administered either before surgery (pre-habilitation) or after surgery 
      (rehabilitation). Patients in the second RCT received additional supervised 
      exercise sessions. Functional capacity was assessed with the 6-minute walk test 
      (6 MWT) at baseline, before surgery, and at 4 and 8 weeks after surgery. Adjusted 
      logistic regression was used to determine the improvement of the 6-minute walk 
      distance (6MWD). RESULTS: Baseline mean 6MWD of 63 patients in the supervised 
      group was 465.1 m (SD, 115), and that of 77 patients in the nonsupervised group 
      was 407.8 m (SD, 109) (P < 0.01). Perioperative supervised exercise training 
      enhanced further functional capacity and muscle strength when compared with the 
      nonsupervised group (P < 0.01). Those receiving exercise supervision had over two 
      times higher chances to return to baseline after surgery. Supervised 
      pre-habilitation was the best combination (4 weeks OR = 7.71, and at 8 weeks 
      OR = 8.62). CONCLUSION: Supervised exercise training leads to meaningful changes 
      in functional capacity thus accelerating the postoperative return to baseline 
      activities.
CI  - (c) 2018 The Acta Anaesthesiologica Scandinavica Foundation. Published by John 
      Wiley & Sons Ltd.
FAU - Awasthi, Rashami
AU  - Awasthi R
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
FAU - Minnella, Enrico M
AU  - Minnella EM
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
FAU - Ferreira, Vanessa
AU  - Ferreira V
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
FAU - Ramanakumar, Agnihotram V
AU  - Ramanakumar AV
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
FAU - Scheede-Bergdahl, Celena
AU  - Scheede-Bergdahl C
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
FAU - Carli, Francesco
AU  - Carli F
AUID- ORCID: 0000-0003-0610-4057
AD  - Montreal General Hospital, Montreal, Quebec, Canada.
LA  - eng
GR  - Peri-Operative Programme (POP), Department of Anaesthesia/International
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20181108
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/*rehabilitation/*surgery
MH  - Dietary Proteins
MH  - Dietary Supplements
MH  - Digestive System Surgical Procedures/*methods
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Nutrition Therapy
MH  - Recovery of Function
MH  - Relaxation Therapy
MH  - Treatment Outcome
MH  - Walking
EDAT- 2018/11/10 06:00
MHDA- 2020/05/10 06:00
CRDT- 2018/11/10 06:00
PHST- 2018/05/14 00:00 [received]
PHST- 2018/09/18 00:00 [revised]
PHST- 2018/10/05 00:00 [accepted]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2020/05/10 06:00 [medline]
PHST- 2018/11/10 06:00 [entrez]
AID - 10.1111/aas.13292 [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2019 Apr;63(4):461-467. doi: 10.1111/aas.13292. Epub 
      2018 Nov 8.