PMID- 30412134
OWN - NLM
STAT- MEDLINE
DCOM- 20181120
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 43
DP  - 2018 Oct
TI  - Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized 
      trials.
PG  - e12995
LID - 10.1097/MD.0000000000012995 [doi]
LID - e12995
AB  - BACKGROUNDS: Observational studies had suggested an inverse association between 
      whole grain consumption and concentration of inflammatory markers, but evidence 
      from interventional studies was inconsistent. Therefore, we conducted a 
      meta-analysis of randomized trials to have a better understanding of this issue. 
      METHODS: This study has been registered in PROSPERO (ID: CRD42018096533). We 
      searched PubMed, Web of Science, Embase, Medline, and Cochrane Library for 
      articles focusing on the topic from inception to 1 January, 2018. Summary 
      standardized mean difference (SMD) and 95% confidence interval (CI) were 
      calculated by using either random effect model or fixed effect model according to 
      the heterogeneity of included studies. Subgroup analysis was also performed. 
      RESULTS: Totally 9 randomized trials included 838 participants were identified. 
      In a pooled analysis of all studies, consumption of whole grains had an inverse 
      association with inflammatory markers (SMD 0.16, 95% CI, 0.02-0.30), including 
      C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha), 
      Interleukin-1beta (IL-1beta). Specific analyses for CRP and IL-6 yielded that whole 
      grain diet was related with a significant decrease in the concentration of CRP 
      (SMD 0.29, 95% CI, 0.08-0.50) and IL-6 (SMD 0.19, 95% CI, 0.03-0.36). 
      CONCLUSIONS: The evidence suggested that citizens could benefit from increased 
      whole grain intake for reducing systemic inflammation. Further well-designed 
      studies are required to investigate the mechanism under the appearance.
FAU - Xu, Yujie
AU  - Xu Y
AD  - West China School of Nursing and Department of Nursing.
FAU - Wan, Qianyi
AU  - Wan Q
AD  - Department of Gastrointestinal Surgery.
FAU - Feng, Jinhua
AU  - Feng J
AD  - Department of Biliary Surgery, West China Hospital, Sichuan University.
FAU - Du, Liang
AU  - Du L
AD  - Chinese Evidence-Based Medicine/Cochrane Center.
FAU - Li, Ka
AU  - Li K
AD  - Department of nursing, West China Hospital, Sichuan University, Chengdu, China.
FAU - Zhou, Yong
AU  - Zhou Y
AD  - Department of Gastrointestinal Surgery.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - *Diet
MH  - Humans
MH  - Inflammation/*therapy
MH  - Randomized Controlled Trials as Topic
MH  - *Whole Grains
PMC - PMC6221555
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/11/10 06:00
MHDA- 2018/11/21 06:00
PMCR- 2018/10/26
CRDT- 2018/11/10 06:00
PHST- 2018/11/10 06:00 [entrez]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2018/11/21 06:00 [medline]
PHST- 2018/10/26 00:00 [pmc-release]
AID - 00005792-201810260-00077 [pii]
AID - MD-D-18-05053 [pii]
AID - 10.1097/MD.0000000000012995 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Oct;97(43):e12995. doi: 10.1097/MD.0000000000012995.