PMID- 30412160
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 0042-8817 (Print)
IS  - 0042-8817 (Linking)
VI  - 82
IP  - 5
DP  - 2018
TI  - [The efficacy of botulinum therapy in treatment of delayed facial palsy after 
      resection of vestibular schwannoma].
PG  - 81-87
LID - 10.17116/neiro20188205181 [doi]
AB  - Delayed facial palsy is a complication developing 3 or more days after surgery. 
      The etiology and pathogenesis of this condition has not been fully explored, and 
      there are no treatment standards for it. As in the case of Bell's paralysis, 
      glucocorticosteroids (GCSs) are currently used to treat delayed facial palsy. 
      However, patients with contraindications to GCSs need new therapy modalities. 
      AIM: We aimed to evaluate the efficacy and safety of botulinum therapy in 
      patients with delayed facial palsy after neurosurgical interventions. MATERIAL 
      AND METHODS: We examined 33 patients with delayed facial palsy developed 3 or 
      more days after resection of vestibular schwannoma. The main group included 18 
      patients with contraindications to GCSs who received injections of botulinum 
      toxin A (BTA) into the facial muscles of the healthy side for muscle relaxation. 
      The comparison group consisted of 15 patients who received a course of 
      prednisolone (1 mg/kg/day) for 5-7 days. The efficacy of treatment was assessed 
      using the House-Brackmann scale and Clinical Global Impression Scale. The 
      follow-up period after therapy was 3 months. RESULTS: Delayed facial palsy was 
      more common in the following cases: the facial nerve was located near the 
      antero-inferior tumor pole; the tumor was adherent to the facial nerve; the tumor 
      extended in the oral direction; the tumor had with unclear borders and was 11 to 
      30 mm in size. In most patients of both groups, facial muscle palsy developed 
      more than 11 days after surgery. Treatment both in the main and control groups 
      resulted in a significant improvement: complete regression of the facial 
      asymmetry in patients of the main group and comparison groups 3 months after 
      treatment onset was 83.3 and 93.3% (House-Brackmann scale), respectively. 
      CONCLUSION: Botulinum therapy may be recommended for patients with delayed facial 
      palsy developed after vestibular schwannoma resection, who have contraindications 
      to GCSs.
FAU - Akulov, M A
AU  - Akulov MA
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Tanyashin, S V
AU  - Tanyashin SV
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Shimansky, V N
AU  - Shimansky VN
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Usachev, D Yu
AU  - Usachev DY
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Orlova, O R
AU  - Orlova OR
AD  - Sechenov First Moscow State Medical University, Moscow, Russia.
FAU - Zakharov, V O
AU  - Zakharov VO
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Karnaukhov, V V
AU  - Karnaukhov VV
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Kolycheva, M V
AU  - Kolycheva MV
AD  - Burdenko Neurosurgical Institute, Moscow, Russia.
FAU - Khat'kova, S E
AU  - Khat'kova SE
AD  - Treatment and Rehabilitation Center, Moscow, Russia; Burnazyan Federal Medical 
      Biophysical Center, Moscow, Russia.
FAU - Latysheva, K D
AU  - Latysheva KD
AD  - Sechenov First Moscow State Medical University, Moscow, Russia.
FAU - Orlova, A S
AU  - Orlova AS
AD  - Sechenov First Moscow State Medical University, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Effektivnost' botulinoterapii v lechenii otsrochennoi neiropatii litsevogo nerva 
      posle udaleniia nevrinomy slukhovogo nerva.
PL  - Russia (Federation)
TA  - Zh Vopr Neirokhir Im N N Burdenko
JT  - Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
JID - 7809757
RN  - EC 3.4.24.69 (Botulinum Toxins)
SB  - IM
MH  - *Botulinum Toxins/therapeutic use
MH  - *Clostridium botulinum
MH  - Facial Nerve
MH  - *Facial Paralysis/drug therapy/etiology
MH  - Humans
MH  - *Neuroma, Acoustic/surgery
MH  - Neurosurgical Procedures
OTO - NOTNLM
OT  - botulinum toxin A
OT  - delayed facial palsy
OT  - vestibular schwannoma
EDAT- 2018/11/10 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/11/10 06:00
PHST- 2018/11/10 06:00 [entrez]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
AID - 10.17116/neiro20188205181 [doi]
PST - ppublish
SO  - Zh Vopr Neirokhir Im N N Burdenko. 2018;82(5):81-87. doi: 
      10.17116/neiro20188205181.