PMID- 30412277
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200109
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 105
IP  - 4
DP  - 2019 Apr
TI  - Hemodynamic Effects of Intravenous, High-Dose Lipid Emulsion With and Without 
      Metoprolol Infusion in Healthy Volunteers: A Randomized Clinical Trial.
PG  - 1009-1017
LID - 10.1002/cpt.1281 [doi]
AB  - In a double-blinded, randomized, crossover trial, we investigated the hemodynamic 
      effects of high-dose intravenous lipid emulsion (ILE) with/without metoprolol. 
      Ten healthy volunteers each completed 4 trial days (placebo + ILE; 
      metoprolol + placebo; metoprolol + ILE; placebo + placebo) in random order. 
      Metoprolol was administered as an initial bolus (10 mg), followed by an infusion 
      (50 mg) from 5 to 30 minutes. ILE was administered as a bolus at 12.5 minutes 
      (2.5 mL/kg), followed by a 15-minute infusion (0.25 mL/kg per minute). On 
      metoprolol + ILE days (compared with metoprolol + placebo) after 120 minutes, 
      mean heart rates were significantly higher (difference, 5.5 beats per minute 
      (bpm); 95% confidence interval (CI), 3.0-8.1 bpm; P < 0.001), and average 
      relative cardiac output was higher (difference, 10 percentage points; 95% CI, 
      5-15 percentage points; P < 0.001). The hemodynamic effect of ILE developed 
      gradually. ILE had no effect on plasma metoprolol or major adverse events. In 
      conclusion, high-dose ILE has relatively marginal and delayed hemodynamic effects 
      that may have limited clinical relevance in the short-term clinical toxicological 
      setting.
CI  - (c) 2018 The Authors Clinical Pharmacology & Therapeutics (c) 2018 American Society 
      for Clinical Pharmacology and Therapeutics.
FAU - Petersen, Kasper Meidahl
AU  - Petersen KM
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Bogevig, Soren
AU  - Bogevig S
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Petersen, Tonny Studsgaard
AU  - Petersen TS
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Jensen, Thomas Bo
AU  - Jensen TB
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Dalhoff, Kim Peder
AU  - Dalhoff KP
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Henriksen, Trine
AU  - Henriksen T
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Poulsen, Henrik Enghusen
AU  - Poulsen HE
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
FAU - Christensen, Mikkel Bring
AU  - Christensen MB
AD  - Department and laboratory of Clinical Pharmacology, Bispebjerg, and Frederiksberg 
      University Hospital, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20181226
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Fat Emulsions, Intravenous)
RN  - 0 (Lipids)
RN  - GEB06NHM23 (Metoprolol)
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Fat Emulsions, Intravenous/*administration & dosage
MH  - Female
MH  - Healthy Volunteers
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Lipids/*administration & dosage
MH  - Male
MH  - Metoprolol/*administration & dosage
MH  - Young Adult
EDAT- 2018/11/10 06:00
MHDA- 2020/01/10 06:00
CRDT- 2018/11/10 06:00
PHST- 2018/06/11 00:00 [received]
PHST- 2018/10/15 00:00 [accepted]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2018/11/10 06:00 [entrez]
AID - 10.1002/cpt.1281 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2019 Apr;105(4):1009-1017. doi: 10.1002/cpt.1281. Epub 2018 
      Dec 26.