PMID- 3041355
OWN - NLM
STAT- MEDLINE
DCOM- 19880902
LR  - 20220410
IS  - 0891-3668 (Print)
IS  - 0891-3668 (Linking)
VI  - 7
IP  - 5 Suppl
DP  - 1988 May
TI  - Immunoglobulin therapy of neonatal group B streptococcal infections: an overview.
PG  - S13-6
AB  - Group B streptococci (GBS) are a major cause of sepsis and meningitis in newborn 
      babies. Neonatal GBS infections are often rapidly progressive, suggesting that 
      the immunity to GBS is deficient. Studies have shown that opsonic antibody is 
      required for efficient phagocytosis and killing of GBS, and neonatal GBS 
      infections have been associated with diminished levels of anti-GBS antibody. 
      Intravenous immunoglobulin (IVIG) has been shown to provide protective immunity 
      in experimental GBS infection models. However, lot to lot variation in opsonic 
      antibody levels occurs in standard IVIG preparations. Recently hyperimmune 
      anti-GBS IVIG has been prepared with high levels of opsonic and protective 
      antibody to GBS. Hyperimmune IVIG preparations will allow physicians to give 
      higher quantities of specific anti-GBS antibody without having to administer 
      large fluid volumes or large amounts of nonspecific immunoglobulin. In addition 
      specific immunoglobulin preparations will ensure that the IVIG contains reliable 
      antibacterial activity. Although human studies are limited they suggest that IVIG 
      therapy in neonates may be safe and effective in treating neonatal sepsis. 
      However, further studies are necessary to determine the role of IVIG in 
      preventing or treating neonatal infections.
FAU - Fischer, G W
AU  - Fischer GW
AD  - Department of Pediatrics, Uniformed Services University of the Health Sciences, 
      Bethesda, MD 20814.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Opsonin Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/immunology
MH  - Humans
MH  - Immunization, Passive/*methods
MH  - Immunoglobulin G/immunology
MH  - Infant, Newborn
MH  - Infusions, Intravenous
MH  - Opsonin Proteins/administration & dosage/immunology
MH  - Streptococcal Infections/immunology/mortality/*therapy
MH  - Streptococcus agalactiae/immunology
RF  - 30
EDAT- 1988/05/01 00:00
MHDA- 1988/05/01 00:01
CRDT- 1988/05/01 00:00
PHST- 1988/05/01 00:00 [pubmed]
PHST- 1988/05/01 00:01 [medline]
PHST- 1988/05/01 00:00 [entrez]
PST - ppublish
SO  - Pediatr Infect Dis J. 1988 May;7(5 Suppl):S13-6.