PMID- 30413632
OWN - NLM
STAT- MEDLINE
DCOM- 20190828
LR  - 20221207
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 91
IP  - 24
DP  - 2018 Dec 11
TI  - Nationwide prevalence and incidence study of neuromyelitis optica spectrum 
      disorder in Denmark.
PG  - e2265-e2275
LID - 10.1212/WNL.0000000000006645 [doi]
AB  - OBJECTIVES: To estimate the nationwide population-based incidence, prevalence, 
      and geographical distribution of neuromyelitis optica (NMO) spectrum disorder 
      (NMOSD) in Denmark based on the 2015 International Panel for NMO Diagnosis (IPND) 
      criteria. METHODS: We conducted a multicentre, historically prospective study. 
      Data were sourced from the Danish National Patient Registry, the Danish Multiple 
      Sclerosis Registry, departments of neurology, and laboratories providing 
      aquaporin-4 antibody test. Cases were selected based on the 2006 Wingerchuk and 
      the 2015 IPND criteria and were individually validated by an expert panel. 
      RESULTS: We confirmed NMO in 30 cases (2006 criteria) and NMOSD in 56 cases (2015 
      IPND criteria) between 2007 and 2014. Defined by the 2006 criteria, the incidence 
      of NMO was 0.029 per 100,000 person-years (95% confidence interval [CI] 
      0.014-0.051), and the prevalence (aged 16 years and older) was 0.566 per 100,000 
      (95% CI 0.370-0.830). Based on the 2015 IPND criteria, the incidence of NMOSD was 
      0.070 per 100,000 person-years (95% CI 0.046-0.102), and the prevalence (aged 16 
      years and older) was 1.09 per 100,000 (95% CI 0.808-1.440), without regional 
      differences. CONCLUSIONS: Our estimates of incidence and prevalence are similar 
      to other Caucasian population-based studies using the 2015 IPND criteria. We 
      found no geographical clustering in Denmark.
CI  - Copyright (c) 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Papp, Viktoria
AU  - Papp V
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark. 
      papp.vittoria@gmail.com.
FAU - Illes, Zsolt
AU  - Illes Z
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Magyari, Melinda
AU  - Magyari M
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Koch-Henriksen, Nils
AU  - Koch-Henriksen N
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Kant, Matthias
AU  - Kant M
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Pfleger, Claudia Christina
AU  - Pfleger CC
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Roemer, Shanu Faerch
AU  - Roemer SF
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Jensen, Michael Broksgaard
AU  - Jensen MB
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Petersen, Annett Evelyn
AU  - Petersen AE
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Nielsen, Helle Hvilsted
AU  - Nielsen HH
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Rosendahl, Lene
AU  - Rosendahl L
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Mezei, Zsolt
AU  - Mezei Z
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Christensen, Tove
AU  - Christensen T
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Svendsen, Kristina
AU  - Svendsen K
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Hyldgaard Jensen, Poul Erik
AU  - Hyldgaard Jensen PE
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Lydolph, Magnus Christian
AU  - Lydolph MC
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Heegaard, Niels
AU  - Heegaard N
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Frederiksen, Jette Lautrup
AU  - Frederiksen JL
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Sellebjerg, Finn
AU  - Sellebjerg F
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Stenager, Egon
AU  - Stenager E
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
FAU - Petersen, Thor
AU  - Petersen T
AD  - From the Department of Neurology (V.P., K.S., T.P.), Aarhus University Hospital; 
      Department of Neurology (Z.I., H.H.N.), Odense University Hospital; Institute of 
      Clinical Research (Z.I., H.H.N.), Institute of Molecular Biology (H.H.N.), and 
      Department of Regional Health Research, Faculty of Health Sciences (E.S.), 
      University of Southern Denmark, Odense; The Danish Multiple Sclerosis Center 
      (M.M., P.E.H.J., F.S.), Department of Neurology, Rigshospitalet, University of 
      Copenhagen; The Danish Multiple Sclerosis Registry (M.M., N.K.-H.), Department of 
      Neurology, Rigshospitalet, Copenhagen University Hospital; Department of Clinical 
      Epidemiology, Clinical Institute (N.K.-H.), and Department of Biomedicine (T.C.), 
      Aarhus University; MS-Clinic of Southern Jutland (Sonderborg, Esbjerg, Kolding) 
      (M.K., E.S.), Department of Neurology, Hospital of Southern Jutland, Sonderborg; 
      Department of Neurology (C.C.P., Z.M.), Aalborg University Hospital; Multiple 
      Sclerosis Unit (S.F.R.), Department of Neurology, Herlev Hospital, Copenhagen; 
      Department of Neurology (M.B.J.), Nordsjaellands Hospital, Hillerod; Department of 
      Neurology (A.E.P.), Hospital of Southwest Jutland, Esbjerg; Department of 
      Neurology (L.R.), Hospital of Central Denmark Region, Viborg; Department of 
      Autoimmunology and Biomarkers (M.C.L., N.H.), Statens Serum Institut, Copenhagen; 
      and Department of Neurology (J.L.F.), Rigshospitalet Glostrup, Faculty of Health 
      and Medical Sciences, University of Copenhagen, Glostrup, Denmark.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20181109
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2019 Oct 15;93(16):722-723. PMID: 31611316
CIN - Neurology. 2019 Oct 15;93(16):723. PMID: 31611317
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Neuromyelitis Optica/*epidemiology
MH  - Prevalence
MH  - Prospective Studies
MH  - White People
MH  - Young Adult
PMC - PMC6329324
EDAT- 2018/11/11 06:00
MHDA- 2019/08/29 06:00
PMCR- 2018/12/11
CRDT- 2018/11/11 06:00
PHST- 2018/04/17 00:00 [received]
PHST- 2018/08/28 00:00 [accepted]
PHST- 2018/11/11 06:00 [pubmed]
PHST- 2019/08/29 06:00 [medline]
PHST- 2018/11/11 06:00 [entrez]
PHST- 2018/12/11 00:00 [pmc-release]
AID - WNL.0000000000006645 [pii]
AID - NEUROLOGY2018900159 [pii]
AID - 10.1212/WNL.0000000000006645 [doi]
PST - ppublish
SO  - Neurology. 2018 Dec 11;91(24):e2265-e2275. doi: 10.1212/WNL.0000000000006645. 
      Epub 2018 Nov 9.