PMID- 30414207
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 2
DP  - 2019 Feb
TI  - Retracted: Long noncoding RNA THRIL contributes in lipopolysaccharide-induced 
      HK-2 cells injury by sponging miR-34a.
PG  - 1444-1456
LID - 10.1002/jcb.27354 [doi]
AB  - Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown 
      etiology. Nowadays, several long noncoding RNAs (lncRNAs) have been reported as 
      molecular alterations involved in SLE. This study aimed to reveal the function of 
      TNF-related and HNRNPL-related immunoregulatory lncRNA (THRIL) in SLE. Human 
      epithelial HK-2 cells were exposed to lipopolysaccharide (LPS) to mimic an in 
      vitro SLE model. Then, the functions of THRIL, miR-34a, and monocyte 
      chemoattractant protein-1 (MCP-1), as well as their correlations were detected. 
      LncRNA THRIL was highly expressed in the LPS-stimulated cells, and THRIL 
      overexpression aggravated LPS-induced cell damage as cell viability was 
      decreased, and apoptosis and the release of proinflammatory cytokines were 
      increased. THRIL worked as a sponge of microRNA-34a (miR-34a) and it could 
      directly target MCP-1. Furthermore, MCP-1-activated JNK and Wnt/beta-catenin 
      signaling pathways. In conclusion, this study suggested that lncRNA THRIL might 
      be a key regulator participating in LPS-induced injury in HK-2 cells. THRIL 
      overexpression aggravated LPS-induced injury possibly via sponging miR-34a, and 
      thus preventing MCP-1 from degradation by miR-34a. The THRIL/miR-34a/MCP-1 axis 
      might play critical roles in SLE.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Deng, Yao
AU  - Deng Y
AD  - Department of Rheumatology and Immunology, Shengli Oilfield Central Hospital, 
      Dongying, China.
FAU - Luan, Sen
AU  - Luan S
AUID- ORCID: 0000-0002-7083-5156
AD  - Department of Nephrology, Shengli Oilfield Central Hospital, Dongying, China.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Rheumatology and Immunology, Shengli Oilfield Central Hospital, 
      Dongying, China.
FAU - Xiao, Ying
AU  - Xiao Y
AD  - Department of Nephrology, Shengli Oilfield Central Hospital, Dongying, China.
LA  - eng
PT  - Retracted Publication
PT  - Retraction of Publication
DEP - 20181109
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
SB  - IM
RIN - J Cell Biochem. 2021 Nov;122 Suppl 1:S116. PMID: 34288057
OTO - NOTNLM
OT  - lipopolysaccharide
OT  - lncRNA THRIL
OT  - miR-34a
OT  - monocyte chemoattractant protein-1
OT  - systemic lupus erythematosus
EDAT- 2018/11/11 06:00
MHDA- 2018/11/11 06:01
CRDT- 2018/11/11 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/06/22 00:00 [accepted]
PHST- 2018/11/11 06:00 [pubmed]
PHST- 2018/11/11 06:01 [medline]
PHST- 2018/11/11 06:00 [entrez]
AID - 10.1002/jcb.27354 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Feb;120(2):1444-1456. doi: 10.1002/jcb.27354. Epub 2018 Nov 
      9.