PMID- 30414256
OWN - NLM
STAT- MEDLINE
DCOM- 20190424
LR  - 20190424
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 97
IP  - 3
DP  - 2019 May
TI  - Associations of cytokine concentrations in aqueous humour with retinal vascular 
      abnormalities and exudation in Coats' disease.
PG  - 319-324
LID - 10.1111/aos.13971 [doi]
AB  - PURPOSE: To investigate the associations of cytokine concentrations in aqueous 
      humour with the severity of retinal vascular abnormalities, exudation and 
      fibrosis in patients with Coats' disease. METHODS: Aqueous humour samples were 
      collected in 23 paediatric patients (23 eyes) with Coats' disease and six 
      age-matched control patients (six eyes) with congenital cataract in this 
      cross-sectional, case-control study. Through Cytometric Bead Array technology, 
      six angiogenic, inflammatory and fibrotic cytokines were measured for their 
      concentrations in aqueous humour. Ophthalmologic characteristics including 
      retinal vessel abnormalities, exudation and fibrosis of Coats' disease were also 
      clinically evaluated for analysis. RESULTS: The aqueous levels of vascular 
      endothelial growth factor (VEGF) (p = 0.006) and monocyte chemoattractant 
      protein-1 (MCP-1) (p < 0.001) were significantly higher in the Coats' disease 
      group than in the control group. The concentrations of angiogenin were peaked in 
      eyes with first-grade vessels tortuosity (p < 0.001), and also positively 
      correlated with the severity of retinal capillary abnormalities (r = 0.910, 
      p < 0.001). The concentrations of MCP-1 (r = 0.966, p < 0.001) and VEGF (r = 0. 
      765, p = 0.002) were significantly correlated with the extent of retinal 
      exudation. The aqueous humour transforming growth factor-beta (TGFbeta) concentrations 
      were higher in eyes with retinal fibrosis than in non-fibrotic eyes with Coats' 
      disease (p = 0.004). CONCLUSION: In Coats' disease, angiogenin may act as a 
      potential biomarker for retinal vascular abnormalities. The concentrations of 
      VEGF and MCP-1 may positively correlate with the severity of retinal exudation.
CI  - (c) 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Zhang, Juan
AU  - Zhang J
AD  - Department of Ophthalmology at Eye and ENT Hospital, Shanghai Medical College, 
      Fudan University, Shanghai, China.
AD  - Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, 
      Shanghai, China.
FAU - Jiang, Chen
AU  - Jiang C
AD  - Department of Ophthalmology at Eye and ENT Hospital, Shanghai Medical College, 
      Fudan University, Shanghai, China.
AD  - Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, 
      Shanghai, China.
FAU - Ruan, Lu
AU  - Ruan L
AD  - Department of Ophthalmology at Eye and ENT Hospital, Shanghai Medical College, 
      Fudan University, Shanghai, China.
FAU - Huang, Xin
AU  - Huang X
AUID- ORCID: 0000-0001-7988-3202
AD  - Department of Ophthalmology at Eye and ENT Hospital, Shanghai Medical College, 
      Fudan University, Shanghai, China.
AD  - Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, 
      Shanghai, China.
LA  - eng
GR  - 17ZR1404500/Natural Science Foundation of Shanghai/
PT  - Journal Article
DEP - 20181109
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Aqueous Humor/*metabolism
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Cataract/congenital/diagnosis/*metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - Cytokines/*metabolism
MH  - Female
MH  - Fluorescein Angiography
MH  - Fundus Oculi
MH  - Humans
MH  - Laser Coagulation
MH  - Male
MH  - Retinal Telangiectasis/diagnosis/*metabolism/surgery
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence
OTO - NOTNLM
OT  - Coats' disease
OT  - aqueous humour
OT  - cytokine
OT  - retinal exudation
OT  - retinal fibrosis
OT  - retinal vascular abnormalities
EDAT- 2018/11/11 06:00
MHDA- 2019/04/25 06:00
CRDT- 2018/11/11 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/11/11 06:00 [pubmed]
PHST- 2019/04/25 06:00 [medline]
PHST- 2018/11/11 06:00 [entrez]
AID - 10.1111/aos.13971 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2019 May;97(3):319-324. doi: 10.1111/aos.13971. Epub 2018 Nov 9.