PMID- 30415249 OWN - NLM STAT- MEDLINE DCOM- 20190128 LR - 20190328 IS - 1423-0216 (Electronic) IS - 1021-7401 (Linking) VI - 25 IP - 3 DP - 2018 TI - A Rodent Model of Anxiety: The Effect of Perinatal Immune Challenges on Gastrointestinal Inflammation and Integrity. PG - 163-175 LID - 10.1159/000493320 [doi] AB - OBJECTIVES: Gastrointestinal (GI) inflammation and GI integrity deficits are common comorbidities of neuropsychiatric disorders. Ongoing research suggests that these aberrations may be contributing to heightened immune signals that have the potential to disrupt neuronal homeostasis and exacerbate behavioural deficits. The current study aimed to determine whether the well-characterized animal model of neuropsychopathology, the maternal immune activation (MIA) model, produced GI inflammation and integrity disruptions in association with anxiety-like behaviour. METHODS: Pregnant Wistar rats were exposed to the viral mimetic polyriboinosinic:polyribocytidilic acid (polyI:C) on gestational days (GD) 10 and 19. Evidence of ANS activation, GI inflammation, and GI barrier integrity was assessed in both neonatal (postnatal day, P7) and adult (P84) offspring. Anxiety-like behaviour was assessed at P100. RESULTS: Neonatal MIA offspring exhibited an altered intestinal inflammatory profile and evidence of an increase in lymphoid aggregates. MIA neonates also displayed disruptions to GI barrier tight junction protein mRNA. In addition, adult MIA offspring exhibited an increase in anxiety-like behaviours. CONCLUSION: These results indicate that the MIA rat model, which is well documented to produce behavioural, neurochemical, and neuroanatomical abnormalities, also produces GI inflammation and integrity disruptions. We suggest that this model may be a useful tool to elucidate biological pathways associated with neuropsychiatric disorders. CI - (c) 2018 S. Karger AG, Basel. FAU - Hollins, Sharon L AU - Hollins SL AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia, sharon.hollins@newcastle.edu.au. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia, sharon.hollins@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, sharon.hollins@newcastle.edu.au. FAU - Brock, Luke AU - Brock L AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Barreto, Rafael AU - Barreto R AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Harms, Lauren AU - Harms L AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. FAU - Dunn, Ariel AU - Dunn A AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Garcia-Sobrinho, Pedro AU - Garcia-Sobrinho P AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Bruce, Jessica AU - Bruce J AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Dickson, Phillip W AU - Dickson PW AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Walker, Marjorie M AU - Walker MM AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Keely, Simon AU - Keely S AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Hodgson, Deborah M AU - Hodgson DM AD - Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia. AD - Priority Research Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181109 PL - Switzerland TA - Neuroimmunomodulation JT - Neuroimmunomodulation JID - 9422763 RN - 0 (Inflammation Mediators) RN - O84C90HH2L (Poly I-C) SB - IM MH - Animals MH - Anxiety/*chemically induced/*immunology/metabolism MH - Disease Models, Animal MH - Female MH - Gastrointestinal Tract/drug effects/*immunology/metabolism MH - Inflammation/chemically induced/immunology/metabolism MH - Inflammation Mediators/*immunology/metabolism MH - Male MH - Maze Learning/physiology MH - Poly I-C/toxicity MH - Pregnancy MH - Prenatal Exposure Delayed Effects/*chemically induced/*immunology/metabolism MH - Rats MH - Rats, Wistar OTO - NOTNLM OT - Anxiety OT - Gastrointestinal OT - Gut-brain axis OT - Immune response OT - Maternal immune activation EDAT- 2018/11/12 06:00 MHDA- 2019/01/29 06:00 CRDT- 2018/11/12 06:00 PHST- 2018/05/31 00:00 [received] PHST- 2018/08/23 00:00 [accepted] PHST- 2018/11/12 06:00 [pubmed] PHST- 2019/01/29 06:00 [medline] PHST- 2018/11/12 06:00 [entrez] AID - 000493320 [pii] AID - 10.1159/000493320 [doi] PST - ppublish SO - Neuroimmunomodulation. 2018;25(3):163-175. doi: 10.1159/000493320. Epub 2018 Nov 9.