PMID- 30415448
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20200225
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 40
IP  - 2
DP  - 2019 Feb
TI  - Lack of association between dopamine transporter loss and non-motor symptoms in 
      patients with Parkinson's disease: a detailed PET analysis of 12 striatal 
      subregions.
PG  - 311-317
LID - 10.1007/s10072-018-3632-7 [doi]
AB  - INTRODUCTION: Patients with Parkinson's disease (PD) present a variety of 
      non-motor symptoms. However, it remains unclear whether dopamine depletion is 
      related to non-motor symptoms, and which non-motor symptoms are significantly 
      dependent on dopaminergic deficit. METHODS: Forty-one patients with PD who 
      underwent positron emission tomography imaging of dopamine transporters (DATs) 
      were recruited for this study. The striatum was divided into 12 subregions, and 
      DAT activity, as striatal dopaminergic concentration, was calculated in each 
      subregion. In addition to measuring motor symptoms using the Unified Parkinson's 
      Disease Rating Scale-part III (UPDRS-III), various non-motor symptoms were 
      assessed using the Montreal cognitive assessment, frontal assessment battery, 
      Beck depression inventory (BDI), Beck anxiety inventory, PD sleep scale (PDSS), 
      PD fatigue scale, and non-motor symptoms scale (NMSS) for PD. RESULTS: For simple 
      linear regression analyses, dopaminergic depletion in all striatal subregions was 
      negatively correlated with the UPDRS-III score. The most relevant non-motor 
      symptom assessment related to dopaminergic loss in the 12 subregions was NMSS, 
      followed by BDI and PDSS. However, following multiple linear regression analyses, 
      dopaminergic depletion in the 12 striatal subregions was not related with any of 
      the non-motor symptoms. Conversely, dopaminergic deficit in the right anterior 
      and posterior putamen was associated with the UPDRS-III score. CONCLUSIONS: 
      Striatal dopaminergic depletion was not significantly correlated with any of the 
      various non-motor symptoms in PD. Our findings suggest that non-dopaminergic 
      systems are significantly implicated in the pathogenesis of non-motor symptoms in 
      patients with PD.
FAU - Park, Soo Bin
AU  - Park SB
AD  - Department of Radiology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Kwon, Kyum-Yil
AU  - Kwon KY
AUID- ORCID: 0000-0001-5443-0952
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea. denovo78@schmc.ac.kr.
FAU - Lee, Jeong-Yoon
AU  - Lee JY
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Im, Kayeong
AU  - Im K
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Sunwoo, Jun-Sang
AU  - Sunwoo JS
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Lee, Kyung Bok
AU  - Lee KB
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Roh, Hakjae
AU  - Roh H
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Ahn, Moo-Young
AU  - Ahn MY
AD  - Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang 
      University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, 
      Republic of Korea.
FAU - Park, Suyeon
AU  - Park S
AD  - Department of Biostatistics, Soonchunhyang University Hospital, Soonchunhyang 
      University College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Soo-Jong
AU  - Kim SJ
AD  - Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Republic of Korea.
FAU - Oh, Jungsu S
AU  - Oh JS
AD  - Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Republic of Korea.
FAU - Kim, Jae Seung
AU  - Kim JS
AD  - Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Republic of Korea.
LA  - eng
GR  - Not applicable/Soonchunhyang University/
GR  - NRF-2018R1C1B5045312/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20181110
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Dopamine Agents)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Tropanes)
RN  - 155797-99-2 (2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
CIN - Neurol Sci. 2019 Dec;40(12):2635-2636. PMID: 31209585
MH  - Aged
MH  - Antiparkinson Agents/therapeutic use
MH  - Brain Mapping
MH  - Corpus Striatum/*diagnostic imaging/*metabolism
MH  - Dopamine/deficiency
MH  - Dopamine Agents/therapeutic use
MH  - Dopamine Plasma Membrane Transport Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Parkinson Disease/*diagnostic imaging/drug therapy/*metabolism/psychology
MH  - *Positron-Emission Tomography
MH  - Psychiatric Status Rating Scales
MH  - Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tropanes
OTO - NOTNLM
OT  - 18F-FP-CIT PET
OT  - Dopamine depletion
OT  - Dopamine transporter imaging
OT  - Non-motor symptom
OT  - Parkinson's disease
EDAT- 2018/11/12 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/11/12 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2018/11/01 00:00 [accepted]
PHST- 2018/11/12 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/11/12 06:00 [entrez]
AID - 10.1007/s10072-018-3632-7 [pii]
AID - 10.1007/s10072-018-3632-7 [doi]
PST - ppublish
SO  - Neurol Sci. 2019 Feb;40(2):311-317. doi: 10.1007/s10072-018-3632-7. Epub 2018 Nov 
      10.