PMID- 30416654
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 10
IP  - 10
DP  - 2018
TI  - Olfactory ensheathing cells transplantation attenuates chronic cerebral 
      hypoperfusion induced cognitive dysfunction and brain damages by activating 
      Nrf2/HO-1 signaling pathway.
PG  - 3111-3121
AB  - Chronic cerebral hypoperfusion (CCH) has become a crucial factor contributing to 
      neurological disorders and cognitive deficits. Olfactory ensheathing cells (OECs) 
      transplantation has been widely used to repair central nerve systems (CNS) 
      injury, however, whether this intervention has therapeutic effects on CCH-induced 
      cognitive dysfunction and brain damages is still unknown. In this study, we 
      sought to determine the potential therapeutic effects of OECs transplantation on 
      CCH. Two days after the establishment of 2VO rat model, OECs or its medium 
      transplantation were performed via intrastriatal injection. In our study, OECs 
      treatment significantly improved learning and memory in 2VO rats. Transplantation 
      of OECs also significantly reduced brain cell death, neuroinflammation and 
      oxidative stress. Mechanistically, transplantation of OECs increased the 
      expression of nuclear factor-like 2 (Nrf2) and hemeoxygenase 1 (HO-1). Finally, 
      treatment with Brusatol, a Nrf2 inhibitor, markedly abolished the neuroprotective 
      effects of OECs on cognitive decline, oxidative stress, Nrf2 and HO-1 expression. 
      These results demonstrated that OECs transplantation protected CCH-induced 
      cognitive impairment and brain injury by suppressing neuroinflammation and 
      oxidative stress. The activation of Nrf2/HO-1 signaling pathway may contribute to 
      the neuroprotection of OECs transplantation in CCH.
FAU - Yu, Ailing
AU  - Yu A
AD  - Shandong University School of Medicine, Department of Neurology, Taian City 
      Central Hospital Taian 271000, Shandong, China.
FAU - Mao, Leilei
AU  - Mao L
AD  - The Institute of Life Sciences Research Center, Taishan Medical College Taian 
      271000, Shandong, China.
FAU - Zhao, Fangfang
AU  - Zhao F
AD  - Shandong University School of Medicine, Department of Neurology, Taian City 
      Central Hospital Taian 271000, Shandong, China.
FAU - Sun, Baoliang
AU  - Sun B
AD  - Key Laboratory of Cerebral Microcirculation in Universities of Shandong, 
      Department of Neurology, Affiliated Hospital of Taishan Medical College Taian 
      271000, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20181015
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6220231
OTO - NOTNLM
OT  - Chronic cerebral hypoperfusion
OT  - Nrf2/HO-1 pathway
OT  - OECs transplantation
COIS- None.
EDAT- 2018/11/13 06:00
MHDA- 2018/11/13 06:01
PMCR- 2018/10/15
CRDT- 2018/11/13 06:00
PHST- 2018/04/11 00:00 [received]
PHST- 2018/08/04 00:00 [accepted]
PHST- 2018/11/13 06:00 [entrez]
PHST- 2018/11/13 06:00 [pubmed]
PHST- 2018/11/13 06:01 [medline]
PHST- 2018/10/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2018 Oct 15;10(10):3111-3121. eCollection 2018.