PMID- 30417170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2573-7732 (Print)
IS  - 2573-7732 (Electronic)
IS  - 2573-7732 (Linking)
VI  - 2
IP  - 5
DP  - 2018 May
TI  - Therapeutic administration of IL-10 and amphiregulin alleviates chronic skeletal 
      muscle inflammation and damage induced by infection.
PG  - 142-154
LID - 10.4049/immunohorizons.1800024 [doi]
AB  - Maintenance of tissue integrity in skeletal muscle requires the immunomodulatory 
      and regenerative functions of muscle-resident regulatory T cells (Tregs). Chronic 
      skeletal muscle infections, such as with Toxoplasma gondii disrupt normal 
      immuno-regulatory networks and lead to pathogenic changes in Treg function. 
      Specifically, Tregs during chronic T. gondii infection reinforce an inflammatory 
      macrophage bias that exacerbates injury in skeletal muscle. In this study, we 
      investigated whether the aberrations in skeletal muscle Treg function during 
      chronic infection could be overcome by treatment with Treg-related factors 
      associated with enhanced muscle regeneration during sterile injury. We show 
      treatment of chronically infected mice with the Treg promoting therapies, 
      interleukin-2 complexed with anti-IL-2 antibody or interleukin-33 (IL-33), did 
      not restore macrophage dynamics or muscle function, respectively, in vivo. 
      However supplementation of known Treg-derived factors, interleukin-10 (IL-10) and 
      amphiregulin (Areg) improved muscle function and skewed macrophages toward a 
      restorative phenotype in the presence of chronic infection. These shifts in 
      macrophage phenotype are coupled with enhanced physiologic parameters of 
      regeneration. Together, these data suggest that while Treg-mediated 
      immuno-regulation is compromised during chronic skeletal muscle infection, 
      supplementation of canonical Treg-derived factors such as IL-10 and Areg can 
      restore immunologic balance and enhance muscle repair.
FAU - Jin, Richard M
AU  - Jin RM
AD  - Department of Microbiology and Immunology, Jacobs School of Medicine and 
      Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
FAU - Warunek, Jordan
AU  - Warunek J
AD  - Department of Microbiology and Immunology, Jacobs School of Medicine and 
      Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
FAU - Wohlfert, Elizabeth A
AU  - Wohlfert EA
AD  - Department of Microbiology and Immunology, Jacobs School of Medicine and 
      Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
LA  - eng
GR  - R21 AI128284/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Immunohorizons
JT  - ImmunoHorizons
JID - 101708159
PMC - PMC6223302
MID - NIHMS978001
OTO - NOTNLM
OT  - Amphiregulin
OT  - IL10
OT  - Macrophages
OT  - Muscle Infection
OT  - Muscle Injury
OT  - Tregs
EDAT- 2018/11/13 06:00
MHDA- 2018/11/13 06:01
PMCR- 2018/11/08
CRDT- 2018/11/13 06:00
PHST- 2018/11/13 06:00 [entrez]
PHST- 2018/11/13 06:00 [pubmed]
PHST- 2018/11/13 06:01 [medline]
PHST- 2018/11/08 00:00 [pmc-release]
AID - 10.4049/immunohorizons.1800024 [doi]
PST - ppublish
SO  - Immunohorizons. 2018 May;2(5):142-154. doi: 10.4049/immunohorizons.1800024.