PMID- 30419430
OWN - NLM
STAT- MEDLINE
DCOM- 20191217
LR  - 20191217
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 169
DP  - 2019 Feb
TI  - Decarbromodiphenyl ether (BDE-209) promotes monocyte-endothelial adhesion in 
      cultured human aortic endothelial cells through upregulating intercellular 
      adhesion molecule-1.
PG  - 62-71
LID - S0013-9351(18)30567-X [pii]
LID - 10.1016/j.envres.2018.10.035 [doi]
AB  - There is growing evidence that exposure to persistent organic pollutants (POPs) 
      is statistically associated with incidence of cardiovascular disease (CVD) or its 
      risk factors. Decarbromodiphenyl ether (BDE-209) is a new POP which exists 
      extensively in human tissues, but its potential effects on CVD have so far 
      received less focus. The adhesion of circulating monocytes to endothelial cells 
      is one of the critical underlying steps in the initiation and development of CVD. 
      In the present study, we investigated the effect of BDE-209 on the adhesion of 
      THP-1 monocytes to human aortic endothelial cells (HAECs) and identified the 
      molecular mechanisms involved. Our results showed that 6.25, 12.5 and 25 microM of 
      BDE-209 exposures caused significant increases in monocyte-endothelial cell 
      adhesion, in a dose-dependent manner. Mechanistically, BDE-209 exposure increased 
      the expression of intercellular adhesion molecule-1 (ICAM-1). Moreover, the 
      up-regulation of ICAM-1 was accompanied by a decrease in the expression of 
      microRNA-141 (miR-141). Furthermore, the up-regulation of ICAM-1 and the 
      increased adhesion induced by BDE-209 could be reversed by miR-141 supplement. 
      Taken together, our results show that BDE-209 potentiates monocyte-endothelial 
      cell interaction via miR-141/ICAM-1 pathway in HAECs.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Zhi, Hui
AU  - Zhi H
AD  - School of Basic Medical Sciences, Wannan Medical College, Wuhu 241003, China; 
      Department of Hypertension and Vascular Disease, The First Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou 510080, China.
FAU - Wu, Jiang-Ping
AU  - Wu JP
AD  - College of Environmental Science and Engineering, Anhui Normal University, Wuhu 
      241003, China. Electronic address: jpwu@ahnu.edu.cn.
FAU - Lu, Lin-Ming
AU  - Lu LM
AD  - School of Basic Medical Sciences, Wannan Medical College, Wuhu 241003, China.
FAU - Zhang, Xue-Mei
AU  - Zhang XM
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou 510080, China.
FAU - Chen, Xiao-Yun
AU  - Chen XY
AD  - College of Environmental Science and Engineering, Anhui Normal University, Wuhu 
      241003, China.
FAU - Wu, Si-Kang
AU  - Wu SK
AD  - College of Environmental Science and Engineering, Anhui Normal University, Wuhu 
      241003, China.
FAU - Tao, Jun
AU  - Tao J
AD  - Department of Hypertension and Vascular Disease, The First Affiliated Hospital, 
      Sun Yat-sen University, Guangzhou 510080, China. Electronic address: 
      taojungz@yahoo.com.
FAU - Mai, Bi-Xian
AU  - Mai BX
AD  - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of 
      Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181101
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (MIRN141 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0F5N573A2Y (Ether)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Cells, Cultured
MH  - Endothelial Cells
MH  - Endothelium, Vascular
MH  - Ether
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - *MicroRNAs
MH  - Monocytes
OTO - NOTNLM
OT  - BDE-209
OT  - Cardiovascular disease
OT  - Endothelial cells
OT  - ICAM-1
OT  - MicroRNA
EDAT- 2018/11/13 06:00
MHDA- 2019/12/18 06:00
CRDT- 2018/11/13 06:00
PHST- 2018/08/17 00:00 [received]
PHST- 2018/10/27 00:00 [revised]
PHST- 2018/10/27 00:00 [accepted]
PHST- 2018/11/13 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/11/13 06:00 [entrez]
AID - S0013-9351(18)30567-X [pii]
AID - 10.1016/j.envres.2018.10.035 [doi]
PST - ppublish
SO  - Environ Res. 2019 Feb;169:62-71. doi: 10.1016/j.envres.2018.10.035. Epub 2018 Nov 
      1.