PMID- 30420258
OWN - NLM
STAT- MEDLINE
DCOM- 20200311
LR  - 20200311
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Print)
IS  - 1477-5131 (Linking)
VI  - 15
IP  - 1
DP  - 2019 Feb
TI  - Elevated urinary lipocalin-2, interleukin-6 and monocyte chemoattractant 
      protein-1 levels in children with congenital ureteropelvic junction obstruction.
PG  - 44.e1-44.e7
LID - S1477-5131(18)30612-0 [pii]
LID - 10.1016/j.jpurol.2018.10.007 [doi]
AB  - INTRODUCTION: In children with congenital ureteropelvic junction obstruction 
      (UPJO), urinary biomarkers could assist in the diagnosis of renal damage or 
      kidneys at risk for damage. Urinary levels of interleukin-6 (IL6), neutrophil 
      gelatinase-associated lipocalin (LCN2), monocyte chemoattractant protein-1 
      (MCP1), and transforming growth factor-beta1 (TGFB1) proteins have been correlated 
      with renal damage in several contexts. Whether they might be useful non-invasive 
      biomarkers of obstructive nephropathy due to unilateral and bilateral congenital 
      UPJO was tested. PATIENTS AND METHODS: A cohort study was performed at People's 
      Hospital of Xinjiang Uygur Autonomous Region in China. Bladder urine samples from 
      17 patients with UPJO were obtained before surgical intervention and from 17 
      healthy age-matched controls. Levels of IL6, LCN2, MCP1, and TGFB1 were 
      determined by enzyme-linked immunosorbent assay and normalized to urinary 
      creatinine levels. RESULTS: Levels of urinary LCN2, MCP1, and IL6 were 
      significantly elevated in the urine from individuals with UPJO compared with 
      controls (P = 0.0003, P = 0.0003, and P = 0.0073, respectively). Children with 
      bilateral UPJO (n = 5) showed significantly higher levels of IL6, LCN2, and MCP1 
      protein in their urine compared with controls or those with unilateral UPJO 
      (n = 12; P = 0.007, P < 0.0001, and P = 0.0002, respectively). Combining LCN2 and 
      MCP1 slightly improved biomarker performance. DISCUSSION: Urinary biomarkers 
      could be used in obstructed patients to monitor for renal damage and might find 
      particular utility on patients with bilateral UPJO. Monitoring urinary biomarkers 
      and imaging features in untreated patients could provide insights into the 
      natural history of renal damage due to obstruction and will be necessary to test 
      their performance characteristics as biomarkers. CONCLUSIONS: Urinary levels of 
      LCN2 and MCP1 protein are promising biomarkers monitoring children with UPJO, 
      particularly in those with bilateral disease.
CI  - Copyright (c) 2018 Journal of Pediatric Urology Company. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Yu, L
AU  - Yu L
AD  - Xinjiang Institute of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
FAU - Zhou, L
AU  - Zhou L
AD  - Department of Pediatric Surgery, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
FAU - Li, Q
AU  - Li Q
AD  - Xinjiang Institute of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
FAU - Li, S
AU  - Li S
AD  - Department of Pediatric Surgery, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
FAU - Luo, X
AU  - Luo X
AD  - Xinjiang Institute of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China.
FAU - Zhang, C
AU  - Zhang C
AD  - Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
FAU - Wu, B
AU  - Wu B
AD  - Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
FAU - Brooks, J D
AU  - Brooks JD
AD  - Department of Urology, Stanford University School of Medicine, Stanford, CA, USA. 
      Electronic address: jdbrooks@stanford.edu.
FAU - Sun, H
AU  - Sun H
AD  - Xinjiang Institute of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, China. Electronic address: hesun@xjrmyy.com.
LA  - eng
GR  - R01 DK101736/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20181017
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interleukin-6/*urine
MH  - *Kidney Pelvis
MH  - Lipocalin-2/*urine
MH  - Male
MH  - Transforming Growth Factor beta1/*urine
MH  - Ureteral Obstruction/*congenital/*urine
PMC - PMC6401238
MID - NIHMS1512180
OTO - NOTNLM
OT  - LCN2
OT  - MCP1
OT  - Renal damage
OT  - UPJO
OT  - Urinary biomarker
COIS- Conflict of interest None.
EDAT- 2018/11/14 06:00
MHDA- 2020/03/12 06:00
PMCR- 2020/02/01
CRDT- 2018/11/14 06:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/10/05 00:00 [accepted]
PHST- 2018/11/14 06:00 [pubmed]
PHST- 2020/03/12 06:00 [medline]
PHST- 2018/11/14 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - S1477-5131(18)30612-0 [pii]
AID - 10.1016/j.jpurol.2018.10.007 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2019 Feb;15(1):44.e1-44.e7. doi: 10.1016/j.jpurol.2018.10.007. 
      Epub 2018 Oct 17.