PMID- 30420918
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2090-2085 (Print)
IS  - 2090-2093 (Electronic)
IS  - 2090-2093 (Linking)
VI  - 2018
DP  - 2018
TI  - Effectiveness of Integrated Neurocognitive Therapy on Cognitive Impairment and 
      Functional Outcome for Schizophrenia Outpatients.
PG  - 2360697
LID - 10.1155/2018/2360697 [doi]
LID - 2360697
AB  - Cognitive impairment is highly prevalent in patients with schizophrenia and 
      schizoaffective disorder. Many interventions have been developed to treat 
      cognitive deficit, since it has a strong impact on functional outcome; however, 
      there are no integrated interventions targeting multiple neuro- and 
      social-cognitive domains with a particular focus on the generalization of the 
      effects of therapy on the functional outcome. Recently, a group of experts has 
      developed a cognitive remediation group therapy approach called Integrated 
      Neurocognitive Therapy (INT), which includes exercises to improve the MATRICS 
      (Measurement and Treatment Research to Improve Cognition in Schizophrenia) neuro- 
      and social-cognitive domains. This systematic review and meta-analysis aimed to 
      assess the efficacy of this approach. We conducted a search of PubMed, Scopus, 
      Web of Science, and PsycINFO to select primary studies evaluating INT in 
      schizophrenic and schizoaffective patients. The primary outcomes of the 
      meta-analysis included negative and positive symptoms and global functioning. Two 
      randomized controlled trials met inclusion criteria. A total of 217 participants 
      were included. Based on the results from the Positive and Negative Syndrome Scale 
      (PANSS), a significant pooled effect size was observed for negative symptoms, 
      which demonstrated not only an improvement in the patients treated immediately 
      after therapy but also a permanence of positive results at a 9-12-month 
      follow-up. On the other hand, no significant effect size was observed for 
      positive symptoms. In addition, a significant pooled effect size was found for 
      Global Assessment of Functioning (GAF), which shows how INT's integrated approach 
      has lasting positive implications on patients' functional outcome. We concluded 
      that INT might be an effective treatment for negative symptoms and global 
      functioning in patients with schizophrenia, compared to treatment as usual (TAU).
FAU - De Mare, Andreana
AU  - De Mare A
AD  - Sapienza University of Rome, Italy.
FAU - Cantarella, Miriam
AU  - Cantarella M
AD  - Sapienza University of Rome, Italy.
FAU - Galeoto, Giovanni
AU  - Galeoto G
AUID- ORCID: 0000-0002-9043-5686
AD  - Department of Public Health and Infection Disease, Sapienza University of Rome, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181021
PL  - Egypt
TA  - Schizophr Res Treatment
JT  - Schizophrenia research and treatment
JID - 101576450
PMC - PMC6215544
EDAT- 2018/11/14 06:00
MHDA- 2018/11/14 06:01
PMCR- 2018/10/21
CRDT- 2018/11/14 06:00
PHST- 2018/05/31 00:00 [received]
PHST- 2018/10/02 00:00 [revised]
PHST- 2018/10/10 00:00 [accepted]
PHST- 2018/11/14 06:00 [entrez]
PHST- 2018/11/14 06:00 [pubmed]
PHST- 2018/11/14 06:01 [medline]
PHST- 2018/10/21 00:00 [pmc-release]
AID - 10.1155/2018/2360697 [doi]
PST - epublish
SO  - Schizophr Res Treatment. 2018 Oct 21;2018:2360697. doi: 10.1155/2018/2360697. 
      eCollection 2018.