PMID- 30422833
OWN - NLM
STAT- MEDLINE
DCOM- 20200519
LR  - 20200519
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 30
IP  - 2
DP  - 2019 Mar
TI  - Long-term renal outcomes and mortality following renal injury among myocardial 
      infarction patients treated by primary percutaneous intervention.
PG  - 87-92
LID - 10.1097/MCA.0000000000000678 [doi]
AB  - OBJECTIVES: Limited data are present on persistent renal impairment following 
      acute kidney injury (AKI) among ST elevation myocardial infarction (STEMI) 
      patients undergoing primary percutaneous coronary intervention (PCI). We 
      evaluated the incidence and prognostic implications of acute kidney disease 
      (AKD), defined as reduced kidney function for the duration of between 7 and 90 
      days after exposure to an AKI initiating event, as well as long-term renal 
      outcomes among STEMI patients undergoing primary PCI who developed AKI. PATIENTS 
      AND METHODS: We retrospectively studied 225 consecutive STEMI patients who 
      developed AKI. Patients were assessed for the occurrence of AKD and long-term 
      renal outcomes on the basis of serum creatinine levels measured at 7 
      days/hospital discharge and within 90-180 days of renal insult. Mortality was 
      assessed at 90 days and over a period of 1271+/-903 days (range: 2-2130 days) 
      following the renal insult. RESULTS: Progression to AKD occurred in 81/225 (36%) 
      patients and was associated with higher 90-day (35 vs. 11%, P<0.001) and 
      long-term mortality (35 vs. 17%, P<0.001). Normalization of serum creatinine to a 
      level equal/lower than hospital admission level at more than 90 days from renal 
      insult occurred in 41% of patients with AKD, whereas 59% of these patients showed 
      new/progressed chronic kidney disease. In contrast, only 7% of patients without 
      AKD showed the progression of pre-existing renal disease while, in the rest, the 
      serum creatinine level remained stable. CONCLUSION: Progression to AKD following 
      an acute renal insult in STEMI is frequent and associated with worse survival and 
      adverse long-term renal outcomes.
FAU - Kofman, Natalia
AU  - Kofman N
AD  - Departments of Cardiology.
FAU - Margolis, Gilad
AU  - Margolis G
AD  - Departments of Cardiology.
FAU - Gal-Oz, Amir
AU  - Gal-Oz A
AD  - Nephrology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Letourneau-Shesaf, Sevan
AU  - Letourneau-Shesaf S
AD  - Departments of Cardiology.
FAU - Keren, Gad
AU  - Keren G
AD  - Departments of Cardiology.
FAU - Rozenbaum, Zach
AU  - Rozenbaum Z
AD  - Departments of Cardiology.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Departments of Cardiology.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - AYI8EX34EU (Creatinine)
RN  - HW8W27HTXX (iodixanol)
SB  - IM
CIN - Coron Artery Dis. 2019 Mar;30(2):93-94. PMID: 30707124
MH  - Acute Kidney Injury/*epidemiology/metabolism
MH  - Aged
MH  - Aged, 80 and over
MH  - Comorbidity
MH  - Contrast Media
MH  - Creatinine/metabolism
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Mortality
MH  - *Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Recovery of Function
MH  - Renal Insufficiency, Chronic/*epidemiology
MH  - Retrospective Studies
MH  - ST Elevation Myocardial Infarction/epidemiology/*therapy
MH  - Triiodobenzoic Acids
EDAT- 2018/11/14 06:00
MHDA- 2020/05/20 06:00
CRDT- 2018/11/14 06:00
PHST- 2018/11/14 06:00 [pubmed]
PHST- 2020/05/20 06:00 [medline]
PHST- 2018/11/14 06:00 [entrez]
AID - 10.1097/MCA.0000000000000678 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2019 Mar;30(2):87-92. doi: 10.1097/MCA.0000000000000678.