PMID- 30423276
OWN - NLM
STAT- MEDLINE
DCOM- 20190213
LR  - 20190215
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 31
IP  - 10
DP  - 2018 Oct
TI  - Clustering of Cardiovascular Risk Factors and Diabetes: A Prospective Cohort 
      Study on the Inner Mongolian Population in China.
PG  - 749-756
LID - 10.3967/bes2018.100 [doi]
AB  - OBJECTIVE: To evaluate the effect of clustering of cardiovascular risk factors 
      (CVRFs) on type 2 diabetes mellitus (T2DM) incidence and identify some high 
      predictive clusters in the Inner Mongolian population in China. METHODS: A total 
      of 1,884 Mongolian individuals aged 20 years or above were followed up from 2002 
      to 2013 and included in the final analysis. We categorized the participants into 
      two subgroups according to the study outcome event. A Cox proportional hazards 
      model was used to evaluate the effect of clustering of CVRFs on the incidence of 
      T2DM. Areas under the curve were used to compare the effect of every cluster on 
      T2DM and identify those having higher predictive value. RESULTS: We found 203 
      persons with T2DM. Subjects with incident T2DM tended to be older, had a higher 
      prevalence of drinking, had higher systolic and diastolic pressures; total 
      cholesterol, triglyceride, low-density lipoprotein cholesterol, and C-reactive 
      protein levels; waist circumference; body mass index; and heart rate and lower 
      HDL-C level than did those without T2DM. The multivariable adjusted hazard ratio 
      (95% confidence interval) of T2DM was calculated based on comparisons with 
      subjects with 0 CVRFs; in participants with 2 and ⪖ 3 factors, the adjusted 
      hazard ratios were 2.257 (1.448, 3.518) and 3.316 (2.119, 5.188), respectively. 
      CONCLUSION: The clustering of CVRFs increased the risk of T2DM. On the basis of 
      fast heart rate, the cluster of abdominal obesity and other CVRFs had higher 
      predictive value for T2DM than the other three CVRF clusters.
CI  - Copyright (c) 2018 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Wang, Ting Ting
AU  - Wang TT
AD  - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of 
      Preventive and Translational Medicine for Geriatric Diseases, Medical College of 
      Soochow University, Suzhou 215123, Jiangsu, China.
FAU - Lin, Bo
AU  - Lin B
AD  - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of 
      Preventive and Translational Medicine for Geriatric Diseases, Medical College of 
      Soochow University, Suzhou 215123, Jiangsu, China.
FAU - Cui, Wen Xiu
AU  - Cui WX
AD  - Harbin Center for Disease Control and Prevention, Harbin 150000, Heilongjiang, 
      China.
FAU - Zhang, Ming Zhi
AU  - Zhang MZ
AD  - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of 
      Preventive and Translational Medicine for Geriatric Diseases, Medical College of 
      Soochow University, Suzhou 215123, Jiangsu, China.
FAU - Zhang, Yong Hong
AU  - Zhang YH
AD  - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of 
      Preventive and Translational Medicine for Geriatric Diseases, Medical College of 
      Soochow University, Suzhou 215123, Jiangsu, China.
FAU - Zhang, Shao Yan
AU  - Zhang SY
AD  - Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of 
      Preventive and Translational Medicine for Geriatric Diseases, Medical College of 
      Soochow University, Suzhou 215123, Jiangsu, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiovascular Diseases/*epidemiology/etiology
MH  - China/epidemiology
MH  - Cluster Analysis
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Cardiovascular risk factors
OT  - Heart rate
OT  - Type 2 diabetes
EDAT- 2018/11/14 06:00
MHDA- 2019/02/14 06:00
CRDT- 2018/11/14 06:00
PHST- 2018/04/05 00:00 [received]
PHST- 2018/09/25 00:00 [accepted]
PHST- 2018/11/14 06:00 [entrez]
PHST- 2018/11/14 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
AID - 10.3967/bes2018.100 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2018 Oct;31(10):749-756. doi: 10.3967/bes2018.100.