PMID- 30423280
OWN - NLM
STAT- MEDLINE
DCOM- 20190213
LR  - 20190215
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 31
IP  - 10
DP  - 2018 Oct
TI  - Hormetic Effects of Yttrium on Male Sprague-Dawley Rats.
PG  - 777-780
LID - 10.3967/bes2018.104 [doi]
AB  - To evaluate hormesis induced by Yttrium (Y) nitrate in male rats, Y was offered 
      to F0 mother rats and F1 offspring at concentrations of 0, 20, 80, and 320 ppm 
      daily from gestational day (GD) 0 through postnatal day 70 (PND 70). The F1 
      offspring were evaluated with respect to motor function, learning and memory, and 
      histopathology. Administration of Y improved motor function in a dose dependent 
      manner. In the 20 ppm group, body weight and spatial learning and memory were 
      increased, while the latter was decreased in the 320 ppm group. Additionally, in 
      the 20 ppm and 80 ppm, but not the 320 ppm groups, Y reduced the anogenital 
      distance, which indicated an anti-androgen effect. These results suggest that Y 
      follows a hormetic concentration-related trend with an inverted U-shape.
CI  - Copyright (c) 2018 The Editorial Board of Biomedical and Environmental Sciences. 
      Published by China CDC. All rights reserved.
FAU - Zhang, Wen Zhong
AU  - Zhang WZ
AD  - North China Institute of Science & Technology, Sanhe 065201, Hebei, China.
FAU - Sun, Na Na
AU  - Sun NN
AD  - China National Center for Food Safety Risk Assessment, Beijing 100021, China.
FAU - Ma, Shang Quan
AU  - Ma SQ
AD  - North China Institute of Science & Technology, Sanhe 065201, Hebei, China.
FAU - Zhao, Zhen Chao
AU  - Zhao ZC
AD  - North China Institute of Science & Technology, Sanhe 065201, Hebei, China.
FAU - Cao, Yu
AU  - Cao Y
AD  - Center for Public Health Surveillance and Information Service, Chinese Center for 
      Disease Control and Prevention, Beijing 102206, China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - North China Institute of Science & Technology, Sanhe 065201, Hebei, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
RN  - 0 (Nitrates)
RN  - 58784XQC3Y (Yttrium)
SB  - IM
MH  - Animals
MH  - Female
MH  - *Hormesis
MH  - Learning/*drug effects
MH  - Male
MH  - Maternal Exposure
MH  - Memory/*drug effects
MH  - Motor Activity/*drug effects
MH  - Nitrates/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Yttrium/*administration & dosage
OTO - NOTNLM
OT  - Anti-androgen
OT  - Cognitive
OT  - Hormesis
OT  - Motor activity
OT  - Yttrium
EDAT- 2018/11/14 06:00
MHDA- 2019/02/14 06:00
CRDT- 2018/11/14 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/09/19 00:00 [accepted]
PHST- 2018/11/14 06:00 [entrez]
PHST- 2018/11/14 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
AID - 10.3967/bes2018.104 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2018 Oct;31(10):777-780. doi: 10.3967/bes2018.104.