PMID- 30424424
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231004
IS  - 2072-666X (Print)
IS  - 2072-666X (Electronic)
IS  - 2072-666X (Linking)
VI  - 9
IP  - 10
DP  - 2018 Sep 25
TI  - Microfabrication of Nonplanar Polymeric Microfluidics.
LID - 10.3390/mi9100491 [doi]
LID - 491
AB  - For four decades, microfluidics technology has been used in exciting, 
      state-of-the-art applications. This paper reports on a novel fabrication approach 
      in which micromachining is used to create nonplanar, three-dimensional 
      microfluidic chips for experiments. Several parameters of micromachining were 
      examined to enhance the smoothness and definition of surface contours in the 
      nonplanar poly(methyl methacrylate) (PMMA) mold inserts. A nonplanar PMMA/PMMA 
      chip and a nonplanar polydimethylsiloxane (PDMS)/PMMA chip were fabricated to 
      demonstrate the efficacy of the proposed approach. In the first case, a S-shape 
      microchannel was fabricated on the nonplanar PMMA substrate and sealed with 
      another nonplanar PMMA via solvent bonding. In the second case, a PDMS membrane 
      was casted from two nonplanar PMMA substrates and bonded on hemispherical PMMA 
      substrate via solvent bonding for use as a microlens array (MLAs). These examples 
      demonstrate the effectiveness of micromachining in the fabrication of nonplanar 
      microfluidic chips directly on a polymeric substrate, as well as in the 
      manufacture of nonplanar mold inserts for use in creating PDMS/PMMA microfluidic 
      chips. This technique facilitates the creation of nonplanar microfluidic chips 
      for applications requiring a three-dimensional space for in vitro 
      characterization.
FAU - Chen, Pin-Chuan
AU  - Chen PC
AD  - Department of Mechanical Engineering, National Taiwan University of Science and 
      Technology, Taipei 10607, Taiwan. pinchuan.chen@gmail.com.
FAU - Lee, Chung-Ying
AU  - Lee CY
AD  - Department of Mechanical Engineering, National Taiwan University of Science and 
      Technology, Taipei 10607, Taiwan. m10403114@mail.ntust.edu.tw.
FAU - Duong, Lynh Huyen
AU  - Duong LH
AD  - Department of Mechanical Engineering, National Taiwan University of Science and 
      Technology, Taipei 10607, Taiwan. duonghuyenlynh@gmail.com.
LA  - eng
GR  - MOST 106-2221-E-011-074/Ministry of Science and Technology, Taiwan/
PT  - Journal Article
DEP - 20180925
PL  - Switzerland
TA  - Micromachines (Basel)
JT  - Micromachines
JID - 101640903
PMC - PMC6215136
OTO - NOTNLM
OT  - microfluidics
OT  - micromachining microfluidics
OT  - nonplanar microfluidic chip
EDAT- 2018/11/15 06:00
MHDA- 2018/11/15 06:01
PMCR- 2018/09/25
CRDT- 2018/11/15 06:00
PHST- 2018/08/21 00:00 [received]
PHST- 2018/09/13 00:00 [revised]
PHST- 2018/09/21 00:00 [accepted]
PHST- 2018/11/15 06:00 [entrez]
PHST- 2018/11/15 06:00 [pubmed]
PHST- 2018/11/15 06:01 [medline]
PHST- 2018/09/25 00:00 [pmc-release]
AID - mi9100491 [pii]
AID - micromachines-09-00491 [pii]
AID - 10.3390/mi9100491 [doi]
PST - epublish
SO  - Micromachines (Basel). 2018 Sep 25;9(10):491. doi: 10.3390/mi9100491.