PMID- 30424929
OWN - NLM
STAT- MEDLINE
DCOM- 20190617
LR  - 20190617
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 24
IP  - 12
DP  - 2018 Dec
TI  - Therapeutic Targeting of Connexin Channels: New Views and Challenges.
PG  - 1036-1053
LID - S1471-4914(18)30201-6 [pii]
LID - 10.1016/j.molmed.2018.10.005 [doi]
AB  - Connexins, in particular connexin 43 (Cx43), function as gap junction channels 
      (GJCs) and hemichannels (HCs). Only recently, specific tools have been developed 
      to study their pleiotropic functions. Based on various protein interaction sites, 
      distinct connexin-mimetic peptides have been established that enable 
      discrimination between the function of HCs and GJCs. Although the precise 
      mechanism of action of most of these peptides is still a matter of debate, an 
      increasing number of studies report on important effects of those compounds in 
      disease models. In this review, we summarize the structure, life cycle, and the 
      most important physiological and pathological functions of both connexin GJCs and 
      HCs. We provide a critical overview on the use of connexin-targeting peptides, in 
      particular targeting Cx43, with a special focus on the remaining questions and 
      hurdles to be taken in the research field of connexin channels.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Delvaeye, Tinneke
AU  - Delvaeye T
AD  - VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 
      9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, 
      Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium; Department of Basic and 
      Applied Medical Sciences, Ghent University, Ghent, 9000, Belgium.
FAU - Vandenabeele, Peter
AU  - Vandenabeele P
AD  - VIB Center for Inflammation Research, Technologiepark 927, Zwijnaarde-Ghent, 
      9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, 
      Technologiepark 927, Zwijnaarde-Ghent, 9052, Belgium; Methusalem Program, Ghent 
      University, Ghent, Belgium; These authors share senior authorship. Electronic 
      address: peter.vandenabeele@irc.vib-ugent.be.
FAU - Bultynck, Geert
AU  - Bultynck G
AD  - Laboratory of Molecular and Cellular Signaling, Department Cellular and Molecular 
      Medicine, KU Leuven, 3000 Leuven, Belgium.
FAU - Leybaert, Luc
AU  - Leybaert L
AD  - Department of Basic and Applied Medical Sciences, Ghent University, Ghent, 9000, 
      Belgium; These authors share senior authorship. Electronic address: 
      luc.leybaert@ugent.be.
FAU - Krysko, Dmitri V
AU  - Krysko DV
AD  - Department of Human Structure and Repair, Ghent University, Ghent, 9000, Belgium; 
      National Research Lobachevsky State University of Nizhni Novgorod, 603950, Nizhny 
      Novgorod, Russia; These authors share senior authorship. Electronic address: 
      dmitri.krysko@ugent.be.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20181110
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
RN  - 0 (Connexin 43)
RN  - 0 (Connexins)
SB  - IM
MH  - Animals
MH  - Connexin 43/metabolism
MH  - Connexins/*metabolism
MH  - Gap Junctions/metabolism
MH  - Humans
OTO - NOTNLM
OT  - connexin43
OT  - gap junctional channel
OT  - hemichannel
OT  - peptides
EDAT- 2018/11/15 06:00
MHDA- 2019/06/18 06:00
CRDT- 2018/11/15 06:00
PHST- 2018/08/14 00:00 [received]
PHST- 2018/10/09 00:00 [revised]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/11/15 06:00 [pubmed]
PHST- 2019/06/18 06:00 [medline]
PHST- 2018/11/15 06:00 [entrez]
AID - S1471-4914(18)30201-6 [pii]
AID - 10.1016/j.molmed.2018.10.005 [doi]
PST - ppublish
SO  - Trends Mol Med. 2018 Dec;24(12):1036-1053. doi: 10.1016/j.molmed.2018.10.005. 
      Epub 2018 Nov 10.