PMID- 30425857
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2090-8016 (Print)
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2018
DP  - 2018
TI  - The First Harmonic of Radial Pulse as an Early Predictor of Silent Coronary 
      Artery Disease and Adverse Cardiac Events in Type 2 Diabetic Patients.
PG  - 5128626
LID - 10.1155/2018/5128626 [doi]
LID - 5128626
AB  - BACKGROUND: It has been reported that harmonics of radial pulse is related to 
      coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). 
      It is still unclear whether or not the first harmonics of the radial pulse 
      spectrum is an early independent predictor of silent coronary artery disease 
      (SCAD) and adverse cardiac events (ACE). OBJECTIVES: To measure the risk of SCAD 
      in patients with T2DM and also to survey whether or not an increment of the first 
      harmonic (C1) of the radial pulse increases ACE. METHODS: 1968 asymptomatic 
      individuals with T2DM underwent radial pulse wave measurement. First harmonic of 
      the radial pressure wave, C1, was calculated. Next, the new occurrence of ACE and 
      the new symptoms and signs of coronary artery disease were recorded. The 
      follow-up period lasted for 14.7 +/- 3.5 months. RESULTS: Out of 1968 asymptomatic 
      individuals with T2DM, ACE was detected in 239 (12%) of them during the follow-up 
      period. The logrank test demonstrated that the cumulative incidence of ACE in 
      patients with C1 above 0.96 was greater than that in those patients with C1 below 
      0.89 (P < 0.01). By comparing the data of patients with C1 smaller than the first 
      quartile and the patients with C1 greater than the third quartile, the hazard 
      ratios were listed as follows: ACE (hazard ratio, 2.29; 95% CI, 1.55-3.37), heart 
      failure (hazard ratio, 2.22; 95% CI, 1.21-4.09), myocardial infarction (hazard 
      ratio, 2.44; 95% CI, 1.51-3.93), left ventricular dysfunction (Hazard ratio, 
      2.01; 95% CI, 0.86-4.70), and new symptoms and signs for coronary artery disease 
      (hazard ratio, 2.03; 95% CI, 1.45-2.84). As C1 increased, the risk for composite 
      ACE (P < 0.001 for trend) and for coronary disease (P < 0.001 for trend) also 
      increased. The hazard ratio and trend for cardiovascular-cause mortality were not 
      significant. CONCLUSIONS: This study showed that C1 of the radial pulse wave is 
      correlated with cardiovascular events. Survival analysis showed that C1 value is 
      an independent predictor of ACE and SCAD in asymptomatic patients with T2DM. 
      Thus, screening for the first harmonic of the radial pulse may improve the risk 
      stratification of cardiac events and SCAD in asymptomatic patients although they 
      had no history of coronary artery disease or angina-related symptom.
FAU - Chang, Chi-Wei
AU  - Chang CW
AUID- ORCID: 0000-0002-8331-7729
AD  - Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan 
      University, Taipei, Taiwan.
FAU - Liao, Kuo-Meng
AU  - Liao KM
AD  - Division of Endocrinology and Metabolism of Zhongxiao Branch of Taipei City 
      Hospital, Taipei, Taiwan.
FAU - Chang, Yi-Ting
AU  - Chang YT
AD  - Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
FAU - Wang, Sheng-Hung
AU  - Wang SH
AD  - Metal Industries Research & Development Centre, Kaohsiung, Taiwan.
FAU - Chen, Ying-Chun
AU  - Chen YC
AD  - Division of Endocrinology and Metabolism of Zhongxiao Branch of Taipei City 
      Hospital, Taipei, Taiwan.
FAU - Wang, Gin-Chung
AU  - Wang GC
AD  - JinMu Health Technology, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20181023
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC6218742
EDAT- 2018/11/15 06:00
MHDA- 2018/11/15 06:01
PMCR- 2018/10/23
CRDT- 2018/11/15 06:00
PHST- 2018/07/05 00:00 [received]
PHST- 2018/09/11 00:00 [revised]
PHST- 2018/09/23 00:00 [accepted]
PHST- 2018/11/15 06:00 [entrez]
PHST- 2018/11/15 06:00 [pubmed]
PHST- 2018/11/15 06:01 [medline]
PHST- 2018/10/23 00:00 [pmc-release]
AID - 10.1155/2018/5128626 [doi]
PST - epublish
SO  - Cardiol Res Pract. 2018 Oct 23;2018:5128626. doi: 10.1155/2018/5128626. 
      eCollection 2018.