PMID- 30430018
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2052-0034 (Print)
IS  - 2052-0034 (Electronic)
VI  - 6
IP  - 4
DP  - 2018 Nov
TI  - Ileal transposition rapidly improves glucose tolerance and gradually improves 
      insulin resistance in non-obese type 2 diabetic rats.
PG  - 291-297
LID - 10.1093/gastro/goy027 [doi]
AB  - BACKGROUND: Many studies have confirmed that ileal transposition can improve type 
      2 diabetes mellitus (T2DM), accompanied by increased glucagon-like peptide-1 
      (GLP-1). We performed the experiment on diabetic rats to evaluate the effects and 
      mechanisms of ileal transposition on the glycemic metabolism. METHODS: Twenty 
      Goto-Kakizaki (GK) rats were randomly divided into the ileal transposition group 
      (IT group) and the sham operation group (Sham group). Weight, food intake, 
      fasting plasma glucose (FPG), fasting insulin (F-ins), oral glucose tolerance 
      test (OGTT) and GLP-1 were determined at baseline and 1, 4, 8, 16 and 24 weeks 
      post-operatively. The homeostasis model assessment-insulin resistance (HOMA-IR) 
      index and the area under the curve (AUC) during OGTT were measured. Histological 
      determination of the GLP-1 receptor (GLP-1R) was performed on the pancreas and 
      ileum 24 weeks post-operatively. RESULTS: In comparison with the Sham group, the 
      IT group showed a higher GLP-1 level and lower AUC at 4, 8, 16 and 24 weeks 
      post-operatively (all P < 0.05) and a lower FPG, F-ins levels and HOMA-IR at 8, 
      16 and 24 weeks post-operatively (all P < 0.05). Compared with baseline levels, 
      the plasma GLP-1, AUC and FPG levels decreased significantly at each 
      post-operative time point in the IT group (all P < 0.05), but not in the Sham 
      group (all P > 0.05); F-ins and HOMA-IR significantly decreased at 8, 16 and 
      24 weeks post-operatively in the IT group (all P < 0.05). GLP-1R expression in 
      the IT group was significantly higher than that of the Sham group in both the 
      pancreas and the ileum at 24 weeks post-operatively (P < 0.05). CONCLUSIONS: 
      Ileal transposition ameliorated glucose metabolism without reduction in weight or 
      food intake in GK rats, which may be induced by the increased GLP-1 expression. 
      However, the delayed improvement of insulin resistance, accompanied by decreased 
      plasma insulin levels, might not directly result from the increased GLP-1.
FAU - Zhu, Hengliang
AU  - Zhu H
AUID- ORCID: 0000-0003-0111-677X
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong, China.
AD  - Department of Gastrointestinal Surgery, The Seventh Affiliated Hospital, Sun 
      Yat-sen University, Shenzhen, Guangdong, China.
FAU - Wang, Huaiming
AU  - Wang H
AD  - Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen 
      University, Guangzhou, Guangdong, China.
FAU - Zheng, Zhihai
AU  - Zheng Z
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang, China.
FAU - Ye, Bailiang
AU  - Ye B
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang, China.
FAU - Ruan, Xiaojiao
AU  - Ruan X
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang, China.
FAU - Zheng, Xiaofeng
AU  - Zheng X
AD  - Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou, Zhejiang, China.
FAU - Li, Guoxin
AU  - Li G
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20180724
PL  - England
TA  - Gastroenterol Rep (Oxf)
JT  - Gastroenterology report
JID - 101620508
PMC - PMC6225830
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - glucagon-like peptide-1
OT  - glycemic metabolism
OT  - ileal transposition
EDAT- 2018/11/16 06:00
MHDA- 2018/11/16 06:01
PMCR- 2018/07/24
CRDT- 2018/11/16 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/03/04 00:00 [revised]
PHST- 2018/06/26 00:00 [accepted]
PHST- 2018/11/16 06:00 [entrez]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2018/11/16 06:01 [medline]
PHST- 2018/07/24 00:00 [pmc-release]
AID - goy027 [pii]
AID - 10.1093/gastro/goy027 [doi]
PST - ppublish
SO  - Gastroenterol Rep (Oxf). 2018 Nov;6(4):291-297. doi: 10.1093/gastro/goy027. Epub 
      2018 Jul 24.