PMID- 30430019
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2052-0034 (Print)
IS  - 2052-0034 (Electronic)
VI  - 6
IP  - 4
DP  - 2018 Nov
TI  - The role of visceral adipose tissue on improvement in insulin sensitivity 
      following Roux-en-Y gastric bypass: a study in Chinese diabetic patients with 
      mild and central obesity.
PG  - 298-303
LID - 10.1093/gastro/goy024 [doi]
AB  - BACKGROUND: Most Chinese patients with type 2 diabetes mellitus (T2DM) have mild 
      obesity and central obesity. Central obesity is combined with insulin resistance. 
      The aim of this study was to assess the effect of abdominal adipose tissue on 
      insulin-sensitivity improvement after Roux-en-Y gastric bypass (RYGB) in Chinese 
      diabetic patients with mild and central obesity. METHODS: Seventeen T2DM patients 
      with a mean body mass index of 30.3 kg/m(2) were scheduled for laparoscopic RYGB. 
      A hyperinsulinemic-euglycemic clamp and dual-energy X-ray absorptiometry were 
      performed prior to surgery and 3 months after RYGB. The primary end points were 
      the correlations between insulin sensitivity and abdominal adipose tissue, 
      including visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), 
      before and 3 months after RYGB. RESULTS: Indices of peripheral insulin 
      sensitivity, including glucose-disposal rate (M value) and glucose infusion rate, 
      were significantly increased after RYGB. Body-fat mass, VAT and SAT were 
      significantly reduced after RYGB. The pre-operative M value was significantly 
      correlated with VAT mass (r = -0.57, P = 0.02), but not correlated with SAT mass. 
      M value changes after RYGB were highly correlated with changes in VAT mass 
      (r = -0.59, P = 0.01), percentage of VAT mass (r = -0.66, P < 0.01), VAT area 
      (r = -0.56, P = 0.02) and percentage of VAT area (r = -0.57, P = 0.02). 
      CONCLUSIONS: A significant correlation was observed between increased peripheral 
      insulin sensitivity and decreased VAT following RYGB in Chinese patients with 
      mild and central obesity. VAT and SAT were significantly decreased with improved 
      insulin sensitivity after RYGB. VAT mass may be considered as an indication for 
      gastric bypass during patient selection.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
AD  - Department of Gastrointestinal Surgery, First Affiliated Hospital, University of 
      South China, No 69 Chuanshan Road, Hengyang, Hunan, China.
FAU - Zhu, Liyong
AU  - Zhu L
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Su, Zhihong
AU  - Su Z
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Li, Weizheng
AU  - Li W
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Li, Pengzhou
AU  - Li P
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Liu, Shengping
AU  - Liu S
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
FAU - Zhu, Shaihong
AU  - Zhu S
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      No 138 Tongzipo Road, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
DEP - 20180629
PL  - England
TA  - Gastroenterol Rep (Oxf)
JT  - Gastroenterology report
JID - 101620508
EIN - Gastroenterol Rep (Oxf). 2018 Nov;6(4):321. PMID: 30431625
PMC - PMC6225828
OTO - NOTNLM
OT  - Insulin sensitivity
OT  - gastric bypass
OT  - hyperinsulinemic-euglycemic clamp
OT  - non-morbid obesity
OT  - type 2 diabetes mellitus
OT  - visceral adipose tissue
EDAT- 2018/11/16 06:00
MHDA- 2018/11/16 06:01
PMCR- 2018/06/29
CRDT- 2018/11/16 06:00
PHST- 2018/01/15 00:00 [received]
PHST- 2018/03/09 00:00 [revised]
PHST- 2018/05/27 00:00 [accepted]
PHST- 2018/11/16 06:00 [entrez]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2018/11/16 06:01 [medline]
PHST- 2018/06/29 00:00 [pmc-release]
AID - goy024 [pii]
AID - 10.1093/gastro/goy024 [doi]
PST - ppublish
SO  - Gastroenterol Rep (Oxf). 2018 Nov;6(4):298-303. doi: 10.1093/gastro/goy024. Epub 
      2018 Jun 29.