PMID- 30430366
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 10
IP  - 1
DP  - 2019 Feb
TI  - Incidence of Diabetes in the Working Population in Spain: Results from the ICARIA 
      Cohort.
PG  - 57-69
LID - 10.1007/s13300-018-0529-7 [doi]
AB  - INTRODUCTION: Our objective was to evaluate the incidence of type 2 diabetes 
      mellitus (T2DM) in a working population in Spain and to assess associations 
      between its development and several risk factors. METHODS: The ICARIA 
      (Ibermutuamur CArdiovascular RIsk Assessment) cohort (n = 627,523) includes ~3% 
      of Spanish workers. This analysis was undertaken in individuals whose glycaemic 
      status during the index period (May 2004-December 2007) was determined to be 
      normal or indicative of prediabetes [fasting plasma glucose (FPG) 100-125 mg/dl] 
      and who had at least one FPG measurement taken 9 months after a first measurement 
      during follow-up (May 2004-June 2014) (n = 380,366). T2DM patients were defined 
      as those with an FPG >/= 126 mg/day and those who had already been diagnosed with 
      T2DM or were taking antihyperglycaemic medications. RESULTS: The incidence rate 
      of T2DM was 5.0 [95% confidence interval (CI) 4.9-5.1] cases per 1000 
      person-years. Under multivariate logistic regression analysis, the factor showing 
      the strongest association with the occurrence of T2DM was the baseline FPG level, 
      with the likelihood of T2DM almost doubling for every 5 mg/dl increase in 
      baseline FPG between 100 and < 126 mg/dl. The presence of other cardiometabolic 
      risk factors and being a blue-collar worker were also significantly associated 
      with the occurrence of T2DM. CONCLUSIONS: The incidence of T2DM in the working 
      population was within the range encountered in the general population and 
      prediabetes was found to be the strongest risk factor for the development of 
      diabetes. The workplace is an appropriate and feasible setting for the assessment 
      of easily measurable risk factors, such as the presence of prediabetes and other 
      cardiometabolic factors, to facilitate the early detection of individuals at 
      higher risk of diabetes and the implementation of diabetes prevention programmes. 
      FUNDING: Eli Lilly and Co.
FAU - Vazquez, Luis Alberto
AU  - Vazquez LA
AD  - Hospital Universitario Marques de Valdecilla, Departamento de Medicina y 
      Psiquiatria, Universidad de Cantabria, Av. Valdecilla, Santander, Spain.
FAU - Calvo-Bonacho, Eva
AU  - Calvo-Bonacho E
AD  - Ibermutuamur, Mutua colaboradora con la Seguridad Social, Madrid, Spain. 
      EvaCalvo@ibermutuamur.es.
FAU - Reviriego, Jesus
AU  - Reviriego J
AD  - Eli Lilly and Company, Madrid, Spain.
FAU - Garcia-Margallo, Teresa
AU  - Garcia-Margallo T
AD  - Cualtis, Madrid, Spain.
FAU - Caveda, Elena
AU  - Caveda E
AD  - Eli Lilly and Company, Madrid, Spain.
FAU - Goday, Albert
AU  - Goday A
AD  - Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20181114
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC6349293
OTO - NOTNLM
OT  - Blue-collar
OT  - Fasting plasma glucose
OT  - ICARIA
OT  - Occupational medicine
OT  - Prediabetes
OT  - Risk factors
OT  - Spain
OT  - Type 2 diabetes mellitus
OT  - White-collar
OT  - Working population
EDAT- 2018/11/16 06:00
MHDA- 2018/11/16 06:01
PMCR- 2018/11/14
CRDT- 2018/11/16 06:00
PHST- 2018/09/18 00:00 [received]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2018/11/16 06:01 [medline]
PHST- 2018/11/16 06:00 [entrez]
PHST- 2018/11/14 00:00 [pmc-release]
AID - 10.1007/s13300-018-0529-7 [pii]
AID - 529 [pii]
AID - 10.1007/s13300-018-0529-7 [doi]
PST - ppublish
SO  - Diabetes Ther. 2019 Feb;10(1):57-69. doi: 10.1007/s13300-018-0529-7. Epub 2018 
      Nov 14.