PMID- 30431198
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20200227
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Print)
IS  - 1066-5099 (Linking)
VI  - 37
IP  - 3
DP  - 2019 Mar
TI  - Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and 
      Neurogenesis in Neural Stem Cells in the Adult Brain.
PG  - 395-406
LID - 10.1002/stem.2947 [doi]
AB  - It is well documented that adult neural stem cells (NSCs) residing in the 
      subventricular zone (SVZ) and the subgranular zone (SGZ) are induced to 
      proliferate and differentiate into new neurons after injury such as stroke and 
      hypoxia. However, the role of injury-related cues in driving this process and the 
      means by which they communicate with NSCs remains largely unknown. Recently, the 
      coupling of neurogenesis and angiogenesis and the extensive close contact between 
      vascular cells and other niche cells, known as the neurovascular unit (NVU), has 
      attracted interest. Further facilitating communication between blood and NSCs is 
      a permeable blood-brain-barrier (BBB) present in most niches, making vascular 
      cells a potential conduit between systemic signals, such as vascular endothelial 
      growth factor (VEGF), and NSCs in the niche, which could play an important role 
      in regulating neurogenesis. We show that the leaky BBB in stem cell niches of the 
      intact and stroke brain can respond to circulating VEGF(165) to drive induction 
      of the Notch ligand DLL4 (one of the most important cues in angiogenesis) in 
      endothelial cells (ECs), pericytes, and further induce significant proliferation 
      and neurogenesis of stem cells. Stem Cells 2019;37:395-406.
CI  - (c) 2018 The Authors. Stem Cells published by Wiley Periodicals, Inc. on behalf of 
      AlphaMed Press 2018.
FAU - Lin, Ruihe
AU  - Lin R
AD  - Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson 
      University, Philadelphia, Pennsylvania, USA.
AD  - The Joseph and Marie Field Cerebrovascular Research Laboratory, Sidney Kimmel 
      Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Cai, Jingli
AU  - Cai J
AD  - Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson 
      University, Philadelphia, Pennsylvania, USA.
AD  - The Joseph and Marie Field Cerebrovascular Research Laboratory, Sidney Kimmel 
      Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Kenyon, Lawrence
AU  - Kenyon L
AD  - Department of Pathology, Anatomy, & Cell Biology, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Iozzo, Renato
AU  - Iozzo R
AD  - Department of Pathology, Anatomy, & Cell Biology, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Rosenwasser, Robert
AU  - Rosenwasser R
AD  - The Joseph and Marie Field Cerebrovascular Research Laboratory, Sidney Kimmel 
      Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Department of Neurological Surgery, Sidney Kimmel Medical College, Thomas 
      Jefferson University, Philadelphia, Pennsylvania, USA.
FAU - Iacovitti, Lorraine
AU  - Iacovitti L
AUID- ORCID: 0000-0002-2996-2460
AD  - Department of Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson 
      University, Philadelphia, Pennsylvania, USA.
AD  - The Joseph and Marie Field Cerebrovascular Research Laboratory, Sidney Kimmel 
      Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
AD  - Vickie & Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, 
      Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181230
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Receptors, Notch)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, mouse)
RN  - 0 (vascular endothelial growth factor A, rat)
SB  - IM
MH  - Adult Stem Cells/cytology/*metabolism
MH  - Animals
MH  - Blood-Brain Barrier/cytology/*metabolism
MH  - Cell Line
MH  - Male
MH  - Mice
MH  - *Neovascularization, Physiologic
MH  - Neural Stem Cells/cytology/*metabolism
MH  - *Neurogenesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Notch/*metabolism
MH  - *Signal Transduction
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC7028145
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Neural stem cells
OT  - Neurogenesis
OT  - Vascular endothelial growth factor
COIS- The authors indicated no potential conflicts of interest.
EDAT- 2018/11/16 06:00
MHDA- 2020/02/28 06:00
PMCR- 2020/02/18
CRDT- 2018/11/16 06:00
PHST- 2018/05/04 00:00 [received]
PHST- 2018/10/19 00:00 [revised]
PHST- 2018/10/25 00:00 [accepted]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2018/11/16 06:00 [entrez]
PHST- 2020/02/18 00:00 [pmc-release]
AID - STEM2947 [pii]
AID - 10.1002/stem.2947 [doi]
PST - ppublish
SO  - Stem Cells. 2019 Mar;37(3):395-406. doi: 10.1002/stem.2947. Epub 2018 Dec 30.