PMID- 30431610
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 46
DP  - 2018 Nov
TI  - Serum levels of fetuin-A are negatively associated with log transformation levels 
      of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: 
      An observational study at a medical center in Taiwan.
PG  - e13254
LID - 10.1097/MD.0000000000013254 [doi]
LID - e13254
AB  - Fetuin-A is a protein with various biological functions. It plays a role in 
      insulin resistance and arterial calcium deposition. Thyroid dysfunction may 
      affect energy expenditure, glucose metabolism, and the risk of cardiovascular 
      diseases. In the present study, we compared the serum fetuin-A concentrations in 
      hyperthyroid patients with those in euthyroid patients.We recruited 30 
      newly-diagnosed hyperthyroid patients (the HY group) and treated them with 
      anti-thyroid regimens as clinically indicated. We recruited 30 euthyroid 
      individuals (the EU group) as controls. We compared laboratory parameters at the 
      baseline and at 6 months. We then determined the associations between the levels 
      of fetuin-A and free thyroxine (fT4), thyroid-stimulating hormone (TSH), or log 
      transformation of TSH (logTSH).At the baseline, the HY patients had significantly 
      higher serum fetuin-A levels than the EU patients (median [Q1, Q3]: 735.4 [537.9, 
      843.4] ng/mL vs 561.1[449.2, 670.5] ng/mL, P = .010). At 6 months, the serum 
      fetuin-A levels of the HY patients decreased but were still higher than those of 
      the EU patients (698.4 [627.6, 924.3] ng/mL vs 616.5 [498.2, 727.7] ng/mL, 
      P = .002). At baseline, the serum levels of fetuin-A were negatively associated 
      with logTSH (beta = -53.79, P = .010). At 6 months, the levels of fetuin-A were 
      positively associated with fT4 (beta = 86.91, P = .039), and negatively associated 
      with logTSH (beta = -104.28, P < .001). Changes to the levels of fetuin-A within 6 
      months were negatively associated with changes to logTSH (beta = -57.80, P = .019). 
      The negative associations between fetuin-A levels and logTSH at baseline and at 6 
      months, and the changes during the 6 months remained significant after adjustment 
      for sex and age (beta = -51.72, P = .016; beta = -103.11, P < .001; and beta = -59.36, 
      P = .020, respectively).The patients with hyperthyroidism had higher serum 
      fetuin-A levels than the patients with euthyroidism. In patients with 
      hyperthyroidism, the serum fetuin-A concentrations decreased after the 
      anti-thyroid treatment. In the present study, serum fetuin-A concentrations were 
      negatively associated with logTSH.
FAU - Tseng, Fen-Yu
AU  - Tseng FY
AD  - Department of Internal Medicine, National Taiwan University Hospital, and 
      National Taiwan University College of Medicine.
FAU - Chen, Yen-Ting
AU  - Chen YT
AD  - Graduate Institute of Clinical Medicine, College of Medicine.
FAU - Chi, Yu-Chiao
AU  - Chi YC
AD  - Graduate Institute of Clinical Medicine, College of Medicine.
FAU - Chen, Pei-Lung
AU  - Chen PL
AD  - Department of Internal Medicine, National Taiwan University Hospital, and 
      National Taiwan University College of Medicine.
AD  - Department of Medical Genetics, National Taiwan University Hospital.
AD  - Graduate Institute of Medical Genomics and Proteomics, College of Medicine, 
      National Taiwan University, Taipei, Taiwan.
FAU - Yang, Wei-Shiung
AU  - Yang WS
AD  - Department of Internal Medicine, National Taiwan University Hospital, and 
      National Taiwan University College of Medicine.
AD  - Graduate Institute of Clinical Medicine, College of Medicine.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (AHSG protein, human)
RN  - 0 (alpha-2-HS-Glycoprotein)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
EIN - Medicine (Baltimore). 2019 Apr;98(15):e15298. PMID: 30985733
MH  - Adult
MH  - Euthyroid Sick Syndromes/*blood
MH  - Female
MH  - Humans
MH  - Hyperthyroidism/*blood
MH  - Male
MH  - Taiwan
MH  - Thyrotropin/*blood
MH  - Thyroxine/blood
MH  - alpha-2-HS-Glycoprotein/*analysis
PMC - PMC6257609
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2018/11/16 06:00
MHDA- 2018/11/27 06:00
PMCR- 2018/11/16
CRDT- 2018/11/16 06:00
PHST- 2018/11/16 06:00 [entrez]
PHST- 2018/11/16 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/11/16 00:00 [pmc-release]
AID - 00005792-201811160-00052 [pii]
AID - MD-D-18-05818 [pii]
AID - 10.1097/MD.0000000000013254 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Nov;97(46):e13254. doi: 10.1097/MD.0000000000013254.